| Autor: |
Chen S; Department of Ultrasound in Medicine, Medical Service Community Of People's Hospital of Fenghua, Ningbo, Zhejiang, China., Yan C; Department of Ultrasound in Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Biotechnology & genetic engineering reviews [Biotechnol Genet Eng Rev] 2024 Nov; Vol. 40 (3), pp. 1873-1883. Date of Electronic Publication: 2023 Mar 30. |
| DOI: |
10.1080/02648725.2023.2197186 |
| Abstrakt: |
To explore the value of ultrasound elastography combined with serological indicators in the diagnosis of liver fibrosis in chronic hepatitis B. A total of 156 patients with chronic hepatitis B from April 2020 to February 2022 were enrolled in this study as subjects. They were assigned to the liver fibrosis group (n=115) and the non-liver fibrosis group (n=41) according to whether the patients had liver fibrosis. They were divided into S1 stage (n=48), S2 stage (n=38), and S3 stage (n=29) according to histopathological staging criteria. Shear wave elastography (SWE) values, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), procollagen type III (PCIII), and laminin (LN) were compared among patients in each stage. Spearman's method was utilized to analyze the correlation of liver serum biochemical indicators and SWE value with liver fibrosis. The predictive performance of SWE value and serological indicators was analyzed using receiver operating characteristic curves. According to Spearman's method, the liver fibrosis stage was positively correlated with SWE value. Serological indicators combined with ultrasound elastography can accurately assess the degree of liver fibrosis in patients with chronic hepatitis B and provide a basis for clinical judgment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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