A survey of neurophysiological differentiation across mouse visual brain areas and timescales.

Autor:	Gandhi SR; MindScope Program, Allen Institute, Seattle, WA, United States., Mayner WGP; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States., Marshall W; Department of Mathematics and Statistics, Brock University, St. Catharines, ON, Canada., Billeh YN; MindScope Program, Allen Institute, Seattle, WA, United States., Bennett C; MindScope Program, Allen Institute, Seattle, WA, United States., Gale SD; MindScope Program, Allen Institute, Seattle, WA, United States., Mochizuki C; MindScope Program, Allen Institute, Seattle, WA, United States., Siegle JH; MindScope Program, Allen Institute, Seattle, WA, United States., Olsen S; MindScope Program, Allen Institute, Seattle, WA, United States., Tononi G; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States., Koch C; MindScope Program, Allen Institute, Seattle, WA, United States., Arkhipov A; MindScope Program, Allen Institute, Seattle, WA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in computational neuroscience [Front Comput Neurosci] 2023 Mar 13; Vol. 17, pp. 1040629. Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023).
DOI:	10.3389/fncom.2023.1040629
Abstrakt:	Neurophysiological differentiation (ND), a measure of the number of distinct activity states that a neural population visits over a time interval, has been used as a correlate of meaningfulness or subjective perception of visual stimuli. ND has largely been studied in non-invasive human whole-brain recordings where spatial resolution is limited. However, it is likely that perception is supported by discrete neuronal populations rather than the whole brain. Therefore, here we use Neuropixels recordings from the mouse brain to characterize the ND metric across a wide range of temporal scales, within neural populations recorded at single-cell resolution in localized regions. Using the spiking activity of thousands of simultaneously recorded neurons spanning 6 visual cortical areas and the visual thalamus, we show that the ND of stimulus-evoked activity of the entire visual cortex is higher for naturalistic stimuli relative to artificial ones. This finding holds in most individual areas throughout the visual hierarchy. Moreover, for animals performing an image change detection task, ND of the entire visual cortex (though not individual areas) is higher for successful detection compared to failed trials, consistent with the assumed perception of the stimulus. Together, these results suggest that ND computed on cellular-level neural recordings is a useful tool highlighting cell populations that may be involved in subjective perception. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Gandhi, Mayner, Marshall, Billeh, Bennett, Gale, Mochizuki, Siegle, Olsen, Tononi, Koch and Arkhipov.)
Databáze:	MEDLINE
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