One Health Surveillance Highlights Circulation of Viruses with Zoonotic Potential in Bats, Pigs, and Humans in Viet Nam.

Autor: Latinne A; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam.; Wildlife Conservation Society, Health Program, Bronx, NY 10460, USA., Nga NTT; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam., Long NV; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam., Ngoc PTB; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam., Thuy HB; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam., Predict Consortium, Long NV; Department of Animal Health, Ministry of Agricultural and Rural Development of Viet Nam, Hanoi 11519, Viet Nam., Long PT; Department of Animal Health, Ministry of Agricultural and Rural Development of Viet Nam, Hanoi 11519, Viet Nam., Phuong NT; Regional Animal Health Office No. 6, Ho Chi Minh City 72106, Viet Nam., Quang LTV; Regional Animal Health Office No. 6, Ho Chi Minh City 72106, Viet Nam., Tung N; Department of Animal Health, Ministry of Agricultural and Rural Development of Viet Nam, Hanoi 11519, Viet Nam., Nam VS; National Institute of Hygiene and Epidemiology, Ministry of Health, Hanoi 11611, Viet Nam., Duoc VT; National Institute of Hygiene and Epidemiology, Ministry of Health, Hanoi 11611, Viet Nam., Thinh ND; National Institute of Hygiene and Epidemiology, Ministry of Health, Hanoi 11611, Viet Nam., Schoepp R; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Ricks K; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Inui K; Food and Agriculture Organization of the United Nations (FAO), Country Office for Viet Nam, Hanoi 11112, Viet Nam., Padungtod P; Food and Agriculture Organization of the United Nations (FAO), Country Office for Viet Nam, Hanoi 11112, Viet Nam., Johnson CK; One Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Mazet JAK; One Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Walzer C; Wildlife Conservation Society, Health Program, Bronx, NY 10460, USA.; Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Olson SH; Wildlife Conservation Society, Health Program, Bronx, NY 10460, USA., Fine AE; Wildlife Conservation Society, Viet Nam Country Program, Hanoi 11111, Viet Nam.; Wildlife Conservation Society, Health Program, Bronx, NY 10460, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2023 Mar 20; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 20.
DOI: 10.3390/v15030790
Abstrakt: A One Health cross-sectoral surveillance approach was implemented to screen biological samples from bats, pigs, and humans at high-risk interfaces for zoonotic viral spillover for five viral families with zoonotic potential in Viet Nam. Over 1600 animal and human samples from bat guano harvesting sites, natural bat roosts, and pig farming operations were tested for coronaviruses (CoVs), paramyxoviruses, influenza viruses, filoviruses and flaviviruses using consensus PCR assays. Human samples were also tested using immunoassays to detect antibodies against eight virus groups. Significant viral diversity, including CoVs closely related to ancestors of pig pathogens, was detected in bats roosting at the human-animal interfaces, illustrating the high risk for CoV spillover from bats to pigs in Viet Nam, where pig density is very high. Season and reproductive period were significantly associated with the detection of bat CoVs, with site-specific effects. Phylogeographic analysis indicated localized viral transmission among pig farms. Our limited human sampling did not detect any known zoonotic bat viruses in human communities living close to the bat cave and harvesting bat guano, but our serological assays showed possible previous exposure to Marburg virus-like (Filoviridae), Crimean-Congo hemorrhagic fever virus-like (Bunyaviridae) viruses and flaviviruses. Targeted and coordinated One Health surveillance helped uncover this viral pathogen emergence hotspot.
Databáze: MEDLINE
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