Transmission of canine transmissible venereal tumour between two dogs in the UK.

Autor: Hayes AM; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Schiavo L; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Constantino-Casas F; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Desmas I; Davies Veterinary Specialists, Hitchin, SG53HR, UK., Dobson J; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Draper A; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Elliot J; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.; Southfields Veterinary Specialists, Essex, SS15 6TP, UK., Genain MA; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Wang J; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Murchison EP; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
Jazyk: angličtina
Zdroj: The Journal of small animal practice [J Small Anim Pract] 2023 Sep; Vol. 64 (9), pp. 590-594. Date of Electronic Publication: 2023 Mar 29.
DOI: 10.1111/jsap.13607
Abstrakt: Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog within the UK. Transmission of genital canine transmissible venereal tumour occurred despite neutered status of the second dog. The aggressive course of disease in both cases, which included metastasis, resistance to therapeutic interventions and ultimate euthanasia of both dogs, is described. The diagnosis of canine transmissible venereal tumour was made using a combination of cytology, histology, immunohistochemistry and PCR to detect the LINE-MYC rearrangement. Practitioners unfamiliar with canine transmissible venereal tumour are reminded of this disease of concern, particularly when imported dogs are placed in multi-dog households, irrespective of neuter status.
(© 2023 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association.)
Databáze: MEDLINE
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