| Autor: |
Mączyńska B; Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Medical University, 50-367 Wroclaw, Poland.; Department of Hygiene and Epidemiology, Lower Silesian T. Marciniak Specialist Hospital-Center for Emergency Medicine, 54-049 Wrocław, Poland., Frej-Mądrzak M; Department of Basic Sciences, Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland., Sarowska J; Department of Basic Sciences, Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland., Woronowicz K; Medical Laboratory Synevo, Fieldorfa 2, 50-049 Wroclaw, Poland., Choroszy-Król I; Department of Basic Sciences, Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland., Jama-Kmiecik A; Department of Basic Sciences, Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland. |
| Abstrakt: |
In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative Enterobacterales : Escherichia coli and Klebsiella pneumoniae , isolated from infections in a multi-profile hospital over five years (from 2017 to 2021). Among the practical outcomes of the evaluation of these data will be the possibility of determining changes in susceptibility to the antibiotics used in the hospital. In turn, this will help propose new therapeutic options, especially for empirical therapy that is necessary in severe infections. The analysis of the use of individual groups of antibiotics allowed for identification of the causes of the increasing resistance of Gram-negative bacilli. The highest number of infections whose etiological agent was K. pneumoniae ESBL(+) and E. coli ESBL(+) was observed in 2018. In the analyzed five-year period, the number of multi-resistant (MDR) K. pneumoniae strains increased successively, which seems to be related to the growing use, especially in the pandemic period, of broad-spectrum antibiotics, mainly penicillins with inhibitors, third-generation cephalosporins, and carbapenems. |
