Diabetic foot ulcer: A comprehensive review of pathophysiology and management modalities.

Autor:	Raja JM; Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38119, United States. jraja@uthsc.edu., Maturana MA; Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38119, United States., Kayali S; Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38119, United States., Khouzam A; Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38119, United States., Efeovbokhan N; Department of Cardiology, NEA Baptist Jonesboro, Jonesboro, AR 72401, United States.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2023 Mar 16; Vol. 11 (8), pp. 1684-1693.
DOI:	10.12998/wjcc.v11.i8.1684
Abstrakt:	Diabetic foot ulcer (DFU) is a debilitating and severe manifestation of uncontrolled and prolonged diabetes that presents as ulceration, usually located on the plantar aspect of the foot. Approximately 15% of individuals with diabetes will eventually develop DFU, and 14%-24% of them will require amputation of the ulcerated foot due to bone infection or other ulcer-related complications. The pathologic mechanisms underlying DFU are comprise a triad: Neuropathy, vascular insufficiency, and secondary infection due to trauma of the foot. Standard local and invasive care along with novel approaches like stem cell therapy pave the way to reduce morbidity, decrease amputations, and prevent mortality from DFU. In this manuscript, we review the current literature with focus on the pathophysiology, preventive options, and definitive management of DFU. Competing Interests: Conflict-of-interest statement: The authors state that there are no conflicts of interest to declare. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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