Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer.

Autor: Bilir F; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey. drflzyldz@hotmail.com.; Cumhuriyet Mh Oren Sk Modul Sitesi A21 Kartal, Istanbul, Turkey. drflzyldz@hotmail.com., Arıoz DT; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Arıkan SE; Department of Medical Biology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Yalcın GS; Department of Pathology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Ozdemir C; Department of Pathology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Demir H; Department of Medical Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Chkhikvadze M; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Ozdemir CY; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Cicekli N; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Vatansever N; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Yılmaz S; Department of General Surgery, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2023 Sep; Vol. 308 (3), pp. 941-946. Date of Electronic Publication: 2023 Mar 24.
DOI: 10.1007/s00404-023-07005-9
Abstrakt: Purpose: Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods: In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results: According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the CNH group, 29 of 437 (6.6%) dissected lymph nodes had metastasis. The median OS was the highest in the POLE group (72 months) and lowest in the CNH group (36 months).
Conclusion: Endometrial cancer patients showed significantly different overall and disease-free survival according to the molecular subtypes and it was consistent with the literature, Lymph node metastasis risk was the highest in CNH group. MSI status is important for the lymph node metastasis risk but not all abnormalities, especially PMS2 and MLH1 expression changes showed the highest risk.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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