The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.

Autor: Brunswick CA; Department of Biology, Pennsylvania State University, University Park, PA., Baldwin DJ; Department of Biology, Pennsylvania State University, University Park, PA., Bodinayake KK; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA., McKenna AR; Department of Biology, Pennsylvania State University, University Park, PA., Lo CY; Department of Biology, Pennsylvania State University, University Park, PA., Bellfy L; Department of Biology, Pennsylvania State University, University Park, PA., Urban MW; Department of Biology, Pennsylvania State University, University Park, PA., Stuart EM; Department of Biology, Pennsylvania State University, University Park, PA., Murakami S; Department of Biology, Pennsylvania State University, University Park, PA., Smies CW; Department of Biology, Pennsylvania State University, University Park, PA., Kwapis JL; Department of Biology, Pennsylvania State University, University Park, PA. Electronic address: jlk855@psu.edu.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Jun; Vol. 126, pp. 77-90. Date of Electronic Publication: 2023 Feb 23.
DOI: 10.1016/j.neurobiolaging.2023.02.009
Abstrakt: Aging impairs both circadian rhythms and memory, though the relationship between these impairments is not fully understood. Circadian rhythms are largely dictated by clock genes within the body's central pacemaker, the suprachiasmatic nucleus (SCN), though these genes are also expressed in local clocks throughout the body. As circadian rhythms can directly affect memory performance, one possibility is that memory deficits observed with age are downstream of global circadian rhythm disruptions stemming from the SCN. Here, we demonstrate that expression of clock gene Period1 within a memory-relevant cortical structure, the retrosplenial cortex (RSC), is necessary for incidental learning, and that age-related disruption of Period1 within the RSC-but not necessarily the SCN-contributes to cognitive decline. These data expand the known functions of clock genes beyond maintaining circadian rhythms and suggests that age-associated changes in clock gene expression modulates circadian rhythms and memory performance in a brain region-dependent manner.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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