CD4 T Cell-Dependent and -Independent Roles for IFN-γ in Blood-Stage Malaria.

Autor:	Drewry LL; Department of Pathology, University of Iowa, Iowa City, IA., Pewe LL; Department of Pathology, University of Iowa, Iowa City, IA., Hancox LS; Department of Pathology, University of Iowa, Iowa City, IA., Van de Wall S; Department of Pathology, University of Iowa, Iowa City, IA., Harty JT; Department of Pathology, University of Iowa, Iowa City, IA.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 May 01; Vol. 210 (9), pp. 1305-1313.
DOI:	10.4049/jimmunol.2200899
Abstrakt:	Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection against malarial disease remain largely untested in vivo. Here we used a CD4 T cell-restricted Cre-Lox IFN-γ excision mouse model to test whether and how CD4 T cell-derived IFN-γ controls blood-stage malaria. Although complete absence of IFN-γ compromised control of the acute and the chronic, recrudescent blood-stage infections with P. c. chabaudi, we identified a specific, albeit modest, role for CD4 T cell-derived IFN-γ in limiting parasite burden only during the chronic stages of P. c. chabaudi malaria. CD4 T cell IFN-γ promoted IgG Ab class switching to the IgG2c isotype during P. c. chabaudi malaria in C57BL/6 mice. Unexpectedly, our data do not support gross defects in phagocytic activity in IFN-γ-deficient hosts infected with blood-stage malaria. Together, our data confirm CD4 T cell-dependent roles for IFN-γ but suggest CD4 T cell-independent roles for IFN-γ in immune responses to blood-stage malaria. (Copyright © 2023 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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