Disease associations of excessive daytime sleepiness in multiple sclerosis: A prospective study.

Autor:	Sguigna PV; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA., Toranian S; Department of Neurology, Dell Medical School, University of Texas Austin, Austin, TX, USA., Tardo LM; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA., Blackburn KM; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA., Horton LA; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA., Conger D; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA., Meltzer E; Department of Neurology, Dell Medical School, University of Texas Austin, Austin, TX, USA., Hogan RN; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA.; Department of Ophthalmology, University of Texas Southwestern, Dallas, TX, USA.; Department of Pathology, University of Texas Southwestern, Dallas, TX, USA.; Department of Neurosurgery, University of Texas Southwestern, Dallas, TX, USA., McCreary MC; Department of Neurosurgery, University of Texas Southwestern, Dallas, TX, USA., Zee PC; Center for Circadian and Sleep Medicine, Northwestern University, Chicago, IL, USA.; Department of Neurology, Sleep Medicine, Northwestern University, Chicago, IL, USA., Takahashi JS; Department of Neuroscience and Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Greenberg BM; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis journal - experimental, translational and clinical [Mult Scler J Exp Transl Clin] 2023 Mar 15; Vol. 9 (1), pp. 20552173231159560. Date of Electronic Publication: 2023 Mar 15 (Print Publication: 2023).
DOI:	10.1177/20552173231159560
Abstrakt:	Background: Excessive daytime sleepiness (EDS) in multiple sclerosis (MS) can be a significant source of disability. Despite this, its prevalence as a patient-reported outcome in this condition has not been well established, and its causes are not well understood. Methods: We prospectively assessed EDS as part of an observational study for patients referred for diagnostic neuro-ophthalmological testing. EDS was evaluated by the Epworth Sleepiness Scale (ESS), and visual data were also collected as part of a research protocol. Analysis with patient data was performed following the exclusion of patients with known primary sleep disorders. Results: A total of 69 patients with MS were included in the analysis. The mean ESS was 6.5 with a SD of 4.3. ESS ≥ 10 was present in 23% of the cohort even in the presence of minimal mean neurological disability (Patient Determined Disease Steps (PDDS) = 1.5). The ESS score was not associated with age, sex, disease-related disability, retinal nerve fiber layer (RNFL), or optic neuritis (ON), but displayed an association with visual dysfunction. Conclusions: There is an increased prevalence of EDS in MS. The increased values of the ESS are not explained by other sleep disorders, suggesting separate mechanisms. Further study of the underlying mechanisms is warranted. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2023.)
Databáze:	MEDLINE
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