Association between vitamin B 12 levels and cognitive impairment in older adults.

Autor: Aguilar-Navarro SG; Department of Geriatrics., Carbajal-Silva JC; Department of Geriatrics., Palacios-Hernández MGI; Department of Geriatrics., Gutiérrez-Gutierrez LA; Department of Neurology and Psychiatry. Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán', Mexico City, Mexico., Ávila-Funes JA; Department of Geriatrics., Mimenza-Alvarado AJ; Department of Geriatrics.
Jazyk: angličtina
Zdroj: Gaceta medica de Mexico [Gac Med Mex] 2023; Vol. 159 (1), pp. 32-37.
DOI: 10.24875/GMM.M22000733
Abstrakt: Introduction: Whether vitamin B 12 deficiency is associated with cognitive impairment remains controversial.
Objective: To determine the association between vitamin B 12 serum levels and cognitive performance.
Methods: Two-hundred and forty-one adults aged ≥ 60 years who had serum vitamin B 12 serum levels measurement were included. Physical and cognitive evaluation was carried out, and three groups were formed: normal cognition (NC), mild cognitive impairment (MCI) and dementia. Vitamin B 12 levels were classified as sufficiency (> 400 pg/mL), subclinical deficiency (201-400 pg/mL), and absolute deficiency (≤ 200 pg/mL). Multivariate linear regression analysis was used to evaluate the association between cognitive function and vitamin B 12 levels after controlling for confounding variables.
Results: Mean age was 81.4 ± 8.0 years; 68% were females; 17.8 % and 39.8% had absolute and subclinical vitamin B 12 deficiency, respectively; 80 individuals (33%) met the criteria for MCI, and 70 (29%), for dementia. Those with MCI and dementia had lower vitamin B 12 levels in comparison with those with NC after adjusting for age, gender and educational level (p = 0.019).
Conclusions: A statistically significant association was observed between global cognitive performance and levels of vitamin B 12 .
(Copyright: © 2023 Permanyer.)
Databáze: MEDLINE
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