Structural and functional asymmetry of the neonatal cerebral cortex.

Autor: Williams LZJ; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. logan.williams@kcl.ac.uk.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. logan.williams@kcl.ac.uk., Fitzgibbon SP; Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Bozek J; Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia., Winkler AM; Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Dimitrova R; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Poppe T; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Schuh A; Department of Computing, Imperial College London, London, UK., Makropoulos A; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Cupitt J; Department of Computing, Imperial College London, London, UK., O'Muircheartaigh J; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK., Duff EP; Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.; UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, London, UK., Cordero-Grande L; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, ISCIII, Madrid, Spain., Price AN; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK., Hajnal JV; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK., Rueckert D; Department of Computing, Imperial College London, London, UK.; Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Smith SM; Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Edwards AD; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.; Neonatal Intensive Care Unit, Evelina London Children's Hospital, London, UK., Robinson EC; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. emma.robinson@kcl.ac.uk.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. emma.robinson@kcl.ac.uk.
Jazyk: angličtina
Zdroj: Nature human behaviour [Nat Hum Behav] 2023 Jun; Vol. 7 (6), pp. 942-955. Date of Electronic Publication: 2023 Mar 16.
DOI: 10.1038/s41562-023-01542-8
Abstrakt: Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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