Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation.

Autor: Trevelyan AJ; Newcastle University Biosciences Institute, Medical School, Framlington Place, Newcastle upon Tyne, United Kingdom., Graham RT; Queen Square Institute of Neurology, University College London, United Kingdom., Parrish RR; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA., Codadu NK; Queen Square Institute of Neurology, University College London, United Kingdom.
Jazyk: angličtina
Zdroj: Epilepsy currents [Epilepsy Curr] 2022 Sep 27; Vol. 23 (1), pp. 38-43. Date of Electronic Publication: 2022 Sep 27 (Print Publication: 2023).
DOI: 10.1177/15357597221127163
Abstrakt: Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
Databáze: MEDLINE
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