MarioHeart: Novel In-Vitro Flow Model for Testing Heart Valve Prostheses and Anticoagulant Therapies.

Autor:	Devos M; From the Cardiovascular Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Liesdek OCD; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.; Van Creveldkliniek, Benign Hematology Center, University Medical Center Utrecht and University Utrecht, Utrecht, the Netherlands., Suyker WJL; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands., van Tuijl S; LifeTec Group BV, Eindhoven, the Netherlands., Schutgens REG; Van Creveldkliniek, Benign Hematology Center, University Medical Center Utrecht and University Utrecht, Utrecht, the Netherlands., van de Vosse FN; From the Cardiovascular Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., de Heer LM; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands., Rutten MCM; From the Cardiovascular Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2023 May 01; Vol. 69 (5), pp. e192-e198. Date of Electronic Publication: 2023 Mar 12.
DOI:	10.1097/MAT.0000000000001915
Abstrakt:	Mechanical heart valve (MHV) prostheses present a risk of thromboembolic complications despite antithrombotic therapy. Further steps in the development of more hemocompatible MHVs and new anticoagulants are impeded due to the lack of adequate in-vitro models. With the development of a novel in-vitro model (MarioHeart), a pulsatile flow similar to the arterial circulation is emulated. The MarioHeart design owns unique features as 1) a single MHV within a torus with low surface/volume ratio, 2) a closed loop system, and 3) a dedicated external control system driving the oscillating rotational motion of the torus. For verification purposes, a blood analog fluid seeded with particles was used to assess fluid velocity and flow rate using a speckle tracking method on high-speed video recordings of the rotating model. The flow rate resembled the physiological flow rate in the aortic root, in both shape and amplitude. Additional in-vitro runs with porcine blood showed thrombi on the MHV associated with the suture ring, which is similar to the in-vivo situation. MarioHeart is a simple design which induces well-defined fluid dynamics resulting in physiologically nonturbulent flow without stasis of the blood. MarioHeart seems suitable for testing the thrombogenicity of MHVs and the potential of new anticoagulants. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © ASAIO 2023.)
Databáze:	MEDLINE
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