Biomarkers and their potential for detecting livestock plant poisonings in Western North America.

Autor:	Green BT; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Welch KD; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Lee ST; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Stonecipher CA; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Gardner DR; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Stegelmeier BL; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Davis TZ; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States., Cook D; Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2023 Feb 22; Vol. 10, pp. 1104702. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
DOI:	10.3389/fvets.2023.1104702
Abstrakt:	The United States National Cancer Institute defines a biomarker as: "A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease." In Veterinary Medicine, biomarkers associated with plant poisonings of livestock have great utility. Since grazing livestock poisoned by toxic plants are often found dead, biomarkers of plant poisoning allow for a more rapid postmortem diagnosis and response to prevent further deaths. The presence and concentration of toxins in poisonous plants are biomarkers of risk for livestock poisoning that can be measured by the chemical analysis of plant material. More difficult is, the detection of plant toxins or biomarkers in biological samples from intoxicated or deceased animals. The purpose of this article is to review potential biomarkers of plant poisoning in grazing livestock in the Western North America including recently investigated non-invasive sampling techniques. Plants discussed include larkspur, lupine, water hemlock, swainsonine-containing plants, selenium-containing plants, and pyrrolizidine alkaloid containing plants. Other factors such as animal age and sex that affect plant biomarker concentrations in vivo are also discussed. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Green, Welch, Lee, Stonecipher, Gardner, Stegelmeier, Davis and Cook.)
Databáze:	MEDLINE
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