Gliosarcoma with extensive extracranial metastatic spread and familial coincidence: A case report.

Autor: Friker LL; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany. Electronic address: Lea.Friker@ukbonn.de., Tzaridis T; Division of Neurooncology, Department of Neurology, University Hospital Bonn, Bonn, Germany; Tumor Initiation and Maintenance Programme, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA., Enkirch SJ; Division of Neuroradiology, Department of Radiology, University Hospital Bonn, Bonn, Germany., Lüders C; Institute of Pathology, University Hospital Bonn, Bonn, Germany., Hattingen E; Division of Neuroradiology, Department of Radiology, University Hospital Bonn, Bonn, Germany., Kristiansen G; Institute of Pathology, University Hospital Bonn, Bonn, Germany., Goschzik T; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Waha A; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Lütter C; Department of Radiosurgery and Stereotactic Radiotherapy, MediClin Robert Janker Clinic and MediClin MVZ Bonn, Villenstrasse 8, 53129 Bonn, Germany., Weller J; Division of Neurooncology, Department of Neurology, University Hospital Bonn, Bonn, Germany., Herrlinger U; Division of Neurooncology, Department of Neurology, University Hospital Bonn, Bonn, Germany., Pietsch T; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Gessi M; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Baumert BG; Department of Radiosurgery and Stereotactic Radiotherapy, MediClin Robert Janker Clinic and MediClin MVZ Bonn, Villenstrasse 8, 53129 Bonn, Germany; Institute of Radiation-Oncology, Kantonsspital Graubünden, Loestr. 170, 7000 Chur, Switzerland., Gielen GH; Institute of Neuropathology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany. Electronic address: Gerrit.Gielen@ukbonn.de.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 Apr; Vol. 244, pp. 154399. Date of Electronic Publication: 2023 Mar 07.
DOI: 10.1016/j.prp.2023.154399
Abstrakt: Gliosarcoma is a rare histopathological subtype of glioblastoma. Metastatic spreading is unusual. In this report, we illustrate a case of gliosarcoma with extensive extracranial metastases with confirmation of histological and molecular concordance between the primary tumor and a metastatic lesion of the lung. Only the autopsy revealed the extent of metastatic spread and the hematogenous pattern of metastatic dissemination. Moreover, the case bared a familial coincidence of malignant glial tumors as the patient's son was diagnosed with a high-grade glioma shortly after the patient's death. By molecular analysis (Sanger and next generation panel sequencing), we could confirm that both patient's tumors carried mutations in the TP53 gene. Interestingly, the detected mutations were located in different exons. Altogether, this case draws attention to the fact that sudden clinical aggravation could be caused by the rare phenomenon of metastatic spread and should therefore be always taken into consideration, even at an early disease stage. Furthermore, the presented case highlights the contemporary value of autoptic pathological examination.
Competing Interests: Conflict of Interest Declaration All authors declare that there are no financial or personal potential competing interests.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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