Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study.

Autor: Destro TRDS; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Biazon TMPC; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Pott-Junior H; Departamento de Medicina, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Caruso FCR; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Andaku DK; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Garcia NM; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Bonjorno-Junior JC; Departamento de Medicina, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Borghi-Silva A; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Kawakami DMO; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Castello-Simões V; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil., Mendes RG; Departamento de Fisioterapia, Universidade Federal de São Carlos - São Carlos (SP), Brasil.
Jazyk: English; Portuguese
Zdroj: Revista Brasileira de terapia intensiva [Rev Bras Ter Intensiva] 2022 Oct-Dec; Vol. 34 (4), pp. 461-468. Date of Electronic Publication: 2023 Mar 03.
DOI: 10.5935/0103-507X.20220132-pt
Abstrakt: Objective: To investigate the influence of a passive mobilization session on endothelial function in patients with sepsis.
Methods: This was a quasi-experimental double-blind and single-arm study with a pre- and postintervention design. Twenty-five patients with a diagnosis of sepsis who were hospitalized in the intensive care unit were included. Endothelial function was assessed at baseline (preintervention) and immediately postintervention by brachial artery ultrasonography. Flow mediated dilatation, peak blood flow velocity and peak shear rate were obtained. Passive mobilization consisted of bilateral mobilization (ankles, knees, hips, wrists, elbows and shoulders), with three sets of ten repetitions each, totaling 15 minutes.
Results: After mobilization, we found increased vascular reactivity function compared to preintervention: absolute flow-mediated dilatation (0.57mm ± 0.22 versus 0.17mm ± 0.31; p < 0.001) and relative flow-mediated dilatation (17.1% ± 8.25 versus 5.08% ± 9.16; p < 0.001). Reactive hyperemia peak flow (71.8cm/s ± 29.3 versus 95.3cm/s ± 32.2; p < 0.001) and shear rate (211s ± 113 versus 288s ± 144; p < 0.001) were also increased.
Conclusion: A passive mobilization session increases endothelial function in critical patients with sepsis. Future studies should investigate whether a mobilization program can be applied as a beneficial intervention for clinical improvement of endothelial function in patients hospitalized due to sepsis.
Databáze: MEDLINE
Externí odkaz: