Gold nanoparticles combined baker's yeast as a successful approach for breast cancer treatment.

Autor: Elwakkad A; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Gamal El Din AA; Pathology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Saleh HA; Electron Microscope and Thin Films Department, Physics Research Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Ibrahim NE; Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Hebishy MA; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Mourad HH; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., El-Kassaby MI; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Abou-Seif HS; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt., Elqattan GM; Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St. (El-Tahrir St. Former), Giza, 12622, Dokki, Egypt. gm.el-qattan@nrc.sci.eg.
Jazyk: angličtina
Zdroj: Journal, genetic engineering & biotechnology [J Genet Eng Biotechnol] 2023 Mar 06; Vol. 21 (1), pp. 27. Date of Electronic Publication: 2023 Mar 06.
DOI: 10.1186/s43141-023-00481-1
Abstrakt: Background: Saccharomyces cerevisiae (S. cerevisiae) has been demonstrated in vitro to sensitize several breast cancer cell lines and to be a safe, non-toxic drug with anti-skin cancer action in mice. Furthermore, plasmonic photothermal treatment using gold nanorods has been authorized as a novel method for in vitro and in vivo cancer therapy.
Results: When compared to tumor-free rats, the treatment with S. cerevisiae conjugated to gold nanospheres (GNSs) lowered Bcl-2 levels while increasing FasL, Bax, cytochrome c, and caspases 8, 9, and 3 levels. Histopathological results showed changes reflecting the ability of nanogold conjugated heat-killed yeast to induce apoptosis is greater than heat-killed yeast alone as the nanogold conjugated with heat-killed yeast showed no tumor, no hyperplasia, no granulation tissue formation, no ulceration, and no suppuration. Nanogold conjugated with heat-killed yeast-treated breast cancer group displayed normal levels of ALT and AST, indicating relatively healthy hepatic cells.
Conclusion: Our results proved that nanogold conjugated heat-killed yeast can initiate apoptosis and can be used as a safe non-invasive method for breast cancer treatment more effectively than the yeast alone. This, in turn, gives us new insight and a future hope for the first time that breast cancer can be treated by non-invasive, simple, safe, and naturally originated method and achieves a hopeful treatment and a novel method for in vivo cancer therapy.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: