The epidemic of the multiresistant dermatophyte Trichophyton indotineae has reached China.

Autor:	Jia S; Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Microbiology, Basic Medical School, Guizhou Medical University, Guiyang, China., Long X; Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Hu W; Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, China., Zhu J; Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, China., Jiang Y; Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, China., Ahmed S; Centre of Expertise in Mycology, Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, Netherlands., de Hoog GS; Centre of Expertise in Mycology, Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, Netherlands., Liu W; Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China.; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Infectious Dermatology Group, Jiangsu Key Laboratory of Molecular Biology of Skin and STIs, Nanjing, Jiangsu, China., Jiang Y; Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Centre of Expertise in Mycology, Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Feb 16; Vol. 13, pp. 1113065. Date of Electronic Publication: 2023 Feb 16 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.1113065
Abstrakt:	Due to its high degree of natural resistance to terbinafine in vitro and its tendency to spread globally from the Indian subcontinent, the emerging dermatophyte Trichophyton indotineae has become a major concern in dermatology. Herein, we present the first report of T. indotineae from mainland China. The transmission of the fungus to Guizhou Province in central China and eventual host susceptibilities were investigated. We studied 31 strains of the T. mentagrophytes complex from outpatient clinics of our hospital collected during the past 5 years. The set comprised four ITS genotypes, two of which were T. mentagrophytes genotype VIII, now known as Trichophyton indotineae ; the earliest isolation in the Guiyang area appeared to date back to 2018. The isolate was derived from an Indian patient, while local Chinese patients had no dermatophytosis caused by this genotype. Reports from around the world indicated that almost all of the globally reported T. indotineae cases originated from the Indian subcontinent and surrounding countries without transmission among native populations, suggesting deviating local conditions or racial differences in immunity against this fungus. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Jia, Long, Hu, Zhu, Jiang, Ahmed, de Hoog, Liu and Jiang.)
Databáze:	MEDLINE
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