Population-Based Mini-Mental State Examination Norms in Adults of Mexican Heritage in the Cameron County Hispanic Cohort.

Autor:	Bukhbinder AS; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Pediatric Neurology, Massachusetts General Hospital, Boston, MA., Hinojosa M; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Harris K; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Li X; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Farrell CM; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Shyer M; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Goodwin N; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Anjum S; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Hasan O; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Cooper S; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Sciba L; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Vargas AF; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Hunter DH; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Ortiz GJ; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Chung K; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Cui L; School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang GQ; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA., Fisher-Hoch SP; Department of Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Brownsville, TX, USA., McCormick JB; Department of Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Brownsville, TX, USA., Schulz PE; Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 92 (4), pp. 1323-1339.
DOI:	10.3233/JAD-220934
Abstrakt:	Background: Accurately identifying cognitive changes in Mexican American (MA) adults using the Mini-Mental State Examination (MMSE) requires knowledge of population-based norms for the MMSE, a scale which has widespread use in research settings. Objective: To describe the distribution of MMSE scores in a large cohort of MA adults, assess the impact of MMSE requirements on their clinical trial eligibility, and explore which factors are most strongly associated with their MMSE scores. Methods: Visits between 2004-2021 in the Cameron County Hispanic Cohort were analyzed. Eligible participants were ≥18 years old and of Mexican descent. MMSE distributions before and after stratification by age and years of education (YOE) were assessed, as was the proportion of trial-aged (50-85- year-old) participants with MMSE <24, a minimum MMSE cutoff most frequently used in Alzheimer's disease (AD) clinical trials. As a secondary analysis, random forest models were constructed to estimate the relative association of the MMSE with potentially relevant variables. Results: The mean age of the sample set (n = 3,404) was 44.4 (SD, 16.0) years old and 64.5% female. Median MMSE was 28 (IQR, 28-29). The percentage of trial-aged participants (n = 1,267) with MMSE <24 was 18.6% overall and 54.3% among the subset with 0-4 YOE (n = 230). The five variables most associated with the MMSE in the study sample were education, age, exercise, C-reactive protein, and anxiety. Conclusion: The minimum MMSE cutoffs in most phase III prodromal-to-mild AD trials would exclude a significant proportion of trial-aged participants in this MA cohort, including over half of those with 0-4 YOE.
Databáze:	MEDLINE
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