Practical Synthesis of 1,4-Dihydropyridines on Heterogeneous Sulfonicmodified Silica (SBA-15-SO 3 H) Catalyst Under Mild Condition.

Autor: Hung TQ; Insitute of Chemistry, VietNam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam., Phuc BV; Insitute of Chemistry, VietNam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam., Loan PTT; Faculty of Chemistry, University of Science, Viet Nam National University Ha Noi, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Ha Noi, Viet Nam., Lan Nhi DT; Faculty of Chemistry, University of Science, Viet Nam National University Ha Noi, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Ha Noi, Viet Nam., Nguyen H; Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Ha Noi, Vietnam., Xuan Vu H; Insitute of Chemistry, VietNam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam., Do DV; Faculty of Chemistry, University of Science, Viet Nam National University Ha Noi, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Ha Noi, Viet Nam., Dang TT; Faculty of Chemistry, University of Science, Viet Nam National University Ha Noi, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Ha Noi, Viet Nam.
Jazyk: angličtina
Zdroj: Current organic synthesis [Curr Org Synth] 2023; Vol. 20 (8), pp. 880-889.
DOI: 10.2174/1570179420666230301143027
Abstrakt: Aims: Synthesis of 1,4-Dihydropyridines (1,4-DHP) using heterogeneous catalyst under mild condition.
Objective: Our objective is to explore new applications of non-metal heterogeneous catalysts in the synthesis of 1,4-DHP derivatives in a greener and more efficient approach.
Methods: A greener and more efficient method for the synthesis of 1,4-DHPs and an asymmetric 1,4-DHP (Felodipine drug) was successfully developed in high yields using a heterogeneous SBA- 15-SO 3 H catalyst.
Results: A series of symmetric 1,4-DHP and an asymmetric 1,4-DHP (Felodipine drug) were successfully prepared in high yields using a heterogeneous SBA-15-SO 3 H catalyst.
Conclusion: The catalyst, SBA-15-SO 3 H, exhibited an efficient catalyst activity for the synthesis of 1,4-DHP derivatives in high yields from the aldehyde, β-ketoester, and NH 4 OAc as a nitrogen source under mild conditions and short reaction time. Bronsted acid sites of this solid catalyst were figured out to play a key role in this transformation. Interestingly, our catalyst is air-stable and can be recycled at least 5 times without losing catalytic activity.
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Databáze: MEDLINE
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