Etiology and Pathophysiology of Diabetes Mellitus in Dogs.
| Autor: | O'Kell AL; Department of Small Animal Clinical Sciences, University of Florida, 2015 Southwest 16th Avenue, Gainesville, FL 32610, USA. Electronic address: aokelldvm@gmail.com., Davison LJ; Royal Veterinary College, Clinical Sciences and Services, Hawkshead Lane, Hertfordshire AL9 7TA, UK. |
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| Jazyk: | angličtina |
| Zdroj: | The Veterinary clinics of North America. Small animal practice [Vet Clin North Am Small Anim Pract] 2023 May; Vol. 53 (3), pp. 493-510. Date of Electronic Publication: 2023 Feb 26. |
| DOI: | 10.1016/j.cvsm.2023.01.004 |
| Abstrakt: | Canine diabetes results from a wide spectrum of clinical pathophysiological processes that cause a similar set of clinical signs. Various causes of insulin deficiency and beta cell loss, insulin resistance, or both characterize the disease, with genetics and environment playing a role. Understanding the genetic and molecular causes of beta cell loss will provide future opportunities for precision medicine, both from a therapeutic and preventative perspective. This review presents current knowledge of the etiology and pathophysiology of canine diabetes, including the importance of disease classification. Examples of potential targets for future precision medicine-based approaches to therapy are discussed. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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