Simultaneous T1, T2, and T2* Mapping of Carotid Plaque: The SIMPLE* Technique.

Autor:	Wang Y; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Liu X; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Wang J; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Wang Y; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Qi H; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Kong X; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Liu D; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Liu J; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Zheng H; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Xiong F; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Zhang L; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Fu X; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Zhang X; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Guo R; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Qiao H; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Chen Z; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Si D; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.)., Chen H; From the Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Haidian District, Beijing, China 100084 (Yajie Wang, H. Qiao, D.S., H.C.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (X.L., J.W., X.K., D.L., J.L., H.Z., F.X., L.Z., X.F., X.Z.); Philips Healthcare, Beijing, China (Yishi Wang); School of Biomedical Engineering, ShanghaiTech University, Shanghai, China (H. Qi); School of Medical Technology, Beijing Institution of Technology, Beijing, China (R.G.); and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Z.C.).
Jazyk:	angličtina
Zdroj:	Radiology [Radiology] 2023 May; Vol. 307 (3), pp. e222061. Date of Electronic Publication: 2023 Feb 28.
DOI:	10.1148/radiol.222061
Abstrakt:	Background Quantitative T1, T2, and T2* measurements of carotid atherosclerotic plaque are important in evaluating plaque vulnerability and monitoring its progression. Purpose To develop a sequence to simultaneously quantify T1, T2, and T2* of carotid plaque. Materials and Methods The simultaneous T1, T2, and T2* mapping of carotid plaque (SIMPLE*) sequence is composed of three modules with different T2 preparation pulses, inversion-recovery pulses, and acquisition schemas. Single-echo data were used for T1 and T2 quantification, while the multiecho (ME) data were used for T2* quantification. The quantitative accuracy of SIMPLE* was tested in a phantom study by comparing its measurements with those of reference standard sequences. In vivo feasibility of the technique was prospectively evaluated between November 2020 and February 2022 in healthy volunteers and participants with carotid atherosclerotic plaque. The Pearson or Spearman correlation test, Student t test, and Wilcoxon rank-sum test were used. Results T1, T2, and T2* estimated with SIMPLE* strongly correlated with inversion-recovery spin-echo (SE) (correlation coefficient [ r ] = 0.99), ME-SE ( r = 0.99), and ME gradient-echo ( r = 0.99) sequences in the phantom study. In five healthy volunteers (mean age, 25 years ± 3 [SD]; three women), measurements were similar between SIMPLE* and modified Look-Locker inversion recovery, or MOLLI (1151 msec ± 71 vs 1098 msec ± 64; P = .14), ME turbo SE (31 msec ± 1 vs 31 msec ± 1; P = .32), and ME turbo field echo (24 msec ± 2 vs 25 msec ± 2; P = .19). In 18 participants with carotid plaque (mean age, 65 years ± 9; 16 men), quantitative T1, T2, and T2* of plaque components were consistent with their signal characteristics on multicontrast images. Conclusion A quantitative technique for simultaneous T1, T2, and T2* mapping of carotid plaque with 100-mm 3 coverage and 0.8-mm 3 resolution was developed using the proposed SIMPLE* sequence and demonstrated high accuracy and in vivo feasibility. © RSNA, 2023 Supplemental material is available for this article.
Databáze:	MEDLINE
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