Effectiveness of Intermittent Hypoxia-Hyperoxia Therapy in Different Pathologies with Possible Metabolic Implications.

Autor: Uzun AB; Department of Pulmonology, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania.; County Clinical Emergency Hospital of Constanta, 145 Tomis Blvd., 900591 Constanta, Romania., Iliescu MG; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania., Stanciu LE; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania., Ionescu EV; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania., Ungur RA; Department of Rehabilitation Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 8 Victor Babes Street, 400012 Cluj-Napoca, Romania., Ciortea VM; Department of Rehabilitation Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 8 Victor Babes Street, 400012 Cluj-Napoca, Romania., Irsay L; Department of Rehabilitation Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 8 Victor Babes Street, 400012 Cluj-Napoca, Romania., Motoașcă I; Clinical Rehabilitation Hospital, 46-50 Viilor Street, 400066 Cluj-Napoca, Romania., Popescu MN; Department of Rehabilitation Medicine, 'Carol Davila' University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania., Popa FL; Physical Medicine and Rehabilitation Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, Victoriei Blvd., 550024 Sibiu, Romania., Pazara L; Department of Physiopathology, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania., Tofolean DE; Department of Pulmonology, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania.; County Clinical Emergency Hospital of Constanta, 145 Tomis Blvd., 900591 Constanta, Romania.
Jazyk: angličtina
Zdroj: Metabolites [Metabolites] 2023 Jan 25; Vol. 13 (2). Date of Electronic Publication: 2023 Jan 25.
DOI: 10.3390/metabo13020181
Abstrakt: Intermittent oxygen therapy (IHT), initially used in the hypoxic administration variant, has been shown to be effective in various pathologies studied, from cardiopulmonary to vascular and metabolic pathologies and more. IHT used to prevent and treat various diseases has thus gained more and more attention as the years have passed. The mechanisms underlying the beneficial effects have been investigated at multiple biological levels, from systemic physiological reactions to genomic regulation. In the last decade, a new method of intermittent oxygen therapy has been developed that combines hypoxic and hyperoxic periods. They can be applied both at rest and during physical exercise, hence the specific indications in sports medicine. It has been hypothesized that replacing normoxia with moderate hyperoxia may increase the adaptive response to the intermittent hypoxic stimulus by upregulating reactive oxygen species and hypoxia-inducible genes. This systematic literature review is based on the "Preferred Reporting Items for Systematic Reviews and Meta-Analysis"-"PRISMA"-methodology, the widely internationally accepted method.
Databáze: MEDLINE
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