Elevation of Pulmonary Artery Pressure in Newborns from High-Altitude Pregnancies Complicated by Preeclampsia.

Autor:	Salinas-Salmon CE; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Murillo-Jauregui C; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Gonzales-Isidro M; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Espinoza-Pinto V; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Mendoza SV; Centro de Salud Tembladerani, La Paz, Bolivia., Ruiz R; Hospital Materno Infantil, La Paz, Bolivia., Vargas R; Hospital de la Mujer, La Paz, Bolivia., Perez Y; Hospital de la Mujer, La Paz, Bolivia., Montaño J; Hospital de la Mujer, La Paz, Bolivia., Toledo L; Hospital Materno Infantil, La Paz, Bolivia., Badner A; Hospital Materno Infantil, La Paz, Bolivia., Jimenez J; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Peñaranda J; Facultad de Medicina, UMSA, La Paz, Bolivia., Romero C; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Aguilar M; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Riveros-Gonzales L; Instituto Boliviano de Biología de Altura (IBBA), UMSA, La Paz, Bolivia., Arana I; Grupo Premio Nobel, La Paz, Bolivia., Villamor E; Maastricht University Medical Center (MUMC+), School for Oncology and Reproduction (GROW), 6202AZ Maastricht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 01; Vol. 12 (2). Date of Electronic Publication: 2023 Feb 01.
DOI:	10.3390/antiox12020347
Abstrakt:	We hypothesized that fetal exposure to the oxidative stress induced by the combined challenge of preeclampsia (PE) and high altitude would induce a significant impairment in the development of pulmonary circulation. We conducted a prospective study in La Paz (Bolivia, mean altitude 3625 m) in which newborns from singleton pregnancies with and without PE were compared (PE group n = 69, control n = 70). We conducted an echocardiographic study in these infants at the median age of two days. The percentage of cesarean deliveries and small for gestational age (SGA) infants was significantly higher in the PE group. Heart rate, respiratory rate, and oxygen saturation did not vary significantly between groups. Estimated pulmonary arterial pressure and pulmonary vascular resistance were 30% higher in newborns exposed to PE and high altitude compared with those exposed only to high altitude. We also detected signs of right ventricular hypertrophy in infants subjected to both exposures. In conclusion, this study provides evidence that the combination of PE and pregnancy at high altitude induces subclinical alterations in the pulmonary circulation of the newborn. Follow-up of this cohort may provide us with valuable information on the potential increased susceptibility to developing pulmonary hypertension or other pulmonary and cardiovascular disorders.
Databáze:	MEDLINE
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