Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19 : Results of a retrospective multicenter neuroimaging-based study from three central European countries.

Autor:	Jensen-Kondering U; Department of Radiology and Neuroradiology, UKSH, Campus Kiel, Kiel, Germany. Ulf.Jensen-Kondering@uksh.de.; Department of Neuroradiology, UKSH, Campus Lübeck, Lübeck, Germany. Ulf.Jensen-Kondering@uksh.de., Maurer CJ; Department of Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Augsburg, Germany., Brudermann HCB; Institute of Medical Biometry and Statistics (IMBS), UKSH, Campus Lübeck, Lübeck, Germany., Ernst M; Institute of Diagnostic and Interventional Neuroradiology, University Medical Center, Göttingen, Germany., Sedaghat S; Department of Radiology and Neuroradiology, UKSH, Campus Kiel, Kiel, Germany.; Department of Radiology, University of California San Diego, San Diego, USA., Margraf NG; Department of Neurology, UKSH, Campus Kiel, Kiel, Germany., Bahmer T; Department of Internal Medicine, UKSH, Campus Kiel, Kiel, Germany., Jansen O; Department of Radiology and Neuroradiology, UKSH, Campus Kiel, Kiel, Germany., Nawabi J; Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte (CCM), Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin Institute of Health, Berlin, Germany.; Berlin Institute of Health (BIH), BIH Biomedical Innovation Academy, Berlin, Germany., Vogt E; Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte (CCM), Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin Institute of Health, Berlin, Germany., Büttner L; Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte (CCM), Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin Institute of Health, Berlin, Germany., Siebert E; Institute of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Bartl M; Department of Neurology, University Medical Center, Göttingen, Germany., Maus V; Department of Diagnostic and Interventional Neuroradiology and Nuclear Medicine, University Medical Center Knappschaftskrankenhaus, Bochum, Germany., Werding G; Department of Diagnostic and Interventional Neuroradiology and Nuclear Medicine, University Medical Center Knappschaftskrankenhaus, Bochum, Germany., Schlamann M; Department of Radiology, Neuroradiology Division, University of Cologne, Cologne, Germany., Abdullayev N; Department of Radiology, Neuroradiology Division, University of Cologne, Cologne, Germany.; GFO Clinics Troisdorf, Radiology and Neuroradiologie, Troisdorf, Germany., Bender B; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Richter V; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Mengel A; Department of Neurology and Stroke, University Hospital Tübingen, Tübingen, Germany., Göpel S; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Berlis A; Department of Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Augsburg, Germany., Grams A; Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria., Ladenhauf V; Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria., Gizewski ER; Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria., Kindl P; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Schulze-Zachau V; Department of Neuroradiology, University Hospital Basel, Basel, Switzerland., Psychogios M; Department of Neuroradiology, University Hospital Basel, Basel, Switzerland., König IR; Institute of Medical Biometry and Statistics (IMBS), UKSH, Campus Lübeck, Lübeck, Germany., Sondermann S; Department of Neuroradiology, UKSH, Campus Lübeck, Lübeck, Germany., Wallis S; Department of Internal Medicine, UKSH, Campus Lübeck, Lübeck, Germany., Brüggemann N; Department of Neurology, UKSH, Campus Lübeck, Lübeck, Germany., Schramm P; Department of Neuroradiology, UKSH, Campus Lübeck, Lübeck, Germany., Neumann A; Department of Neuroradiology, UKSH, Campus Lübeck, Lübeck, Germany.
Jazyk:	angličtina
Zdroj:	Journal of neurology [J Neurol] 2023 May; Vol. 270 (5), pp. 2349-2359. Date of Electronic Publication: 2023 Feb 23.
DOI:	10.1007/s00415-023-11608-2
Abstrakt:	Background: Coronavirus disease 2019 (COVID-19) is an infection which can affect the central nervous system. In this study, we sought to investigate associations between neuroimaging findings with clinical, demographic, blood and cerebrospinal fluid (CSF) parameters, pre-existing conditions and the severity of acute COVID-19. Materials and Methods: Retrospective multicenter data retrieval from 10 university medical centers in Germany, Switzerland and Austria between February 2020 and September 2021. We included patients with COVID-19, acute neurological symptoms and cranial imaging. We collected demographics, neurological symptoms, COVID-19 severity, results of cranial imaging, blood and CSF parameters during the hospital stay. Results: 442 patients could be included. COVID-19 severity was mild in 124 (28.1%) patients (moderate n = 134/30.3%, severe n = 43/9.7%, critical n = 141/31.9%). 220 patients (49.8%) presented with respiratory symptoms, 167 (37.8%) presented with neurological symptoms first. Acute ischemic stroke (AIS) was detected in 70 (15.8%), intracranial hemorrhage (IH) in 48 (10.9%) patients. Typical risk factors were associated with AIS; extracorporeal membrane oxygenation therapy and invasive ventilation with IH. No association was found between the severity of COVID-19 or blood/CSF parameters and the occurrence of AIS or IH. Discussion: AIS was the most common finding on cranial imaging. IH was more prevalent than expected but a less common finding than AIS. Patients with IH had a distinct clinical profile compared to patients with AIS. There was no association between AIS or IH and the severity of COVID-19. A considerable proportion of patients presented with neurological symptoms first. Laboratory parameters have limited value as a screening tool. (© 2023. The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink