Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor.

Autor:	Hocking AJ; From the Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia (Hocking, Prabhakaran, Klebe)., Thomas EM; School of Medicine, University of Adelaide, South Australia, Australia (Thomas, Woods)., Prabhakaran S; From the Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia (Hocking, Prabhakaran, Klebe)., Jolley A; The Department of Surgical Pathology, South Australian Pathology at Flinders Medical Centre, Adelaide, South Australia, Australia (Jolley, Klebe)., Woods SL; School of Medicine, University of Adelaide, South Australia, Australia (Thomas, Woods).; Precision Medicine, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia (Woods)., Soeberg MJ; Asbestos Diseases Research Institute, Bernie Banton Centre, Concord Hospital, Concord, Australia (Soeberg)., Klebe S; From the Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia (Hocking, Prabhakaran, Klebe).; The Department of Surgical Pathology, South Australian Pathology at Flinders Medical Centre, Adelaide, South Australia, Australia (Jolley, Klebe).
Jazyk:	angličtina
Zdroj:	Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2023 Dec 01; Vol. 147 (12), pp. 1446-1450.
DOI:	10.5858/arpa.2022-0283-OA
Abstrakt:	Context.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma. Objective.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos. Design.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time. Results.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations. Conclusions.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere. (© 2023 College of American Pathologists.)
Databáze:	MEDLINE
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