Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.

Autor:	Zhou W; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kanai M; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK., Tsuo K; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hirbo JB; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Wang Y; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bhattacharya A; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Zhao H; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Wolford BN; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Lo Faro V; University of Groningen, UMCG, Department of Ophthalmology, Groningen, the Netherlands.; Department of Clinical Genetics, Amsterdam University Medical Center (AMC), Amsterdam, the Netherlands.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Lopera-Maya EA; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands., Läll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Favé MJ; Ontario Institute for Cancer Research, Toronto, ON, Canada., Partanen JJ; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Chapman SB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Karjalainen J; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Kurki M; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Maasha M; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Chavan S; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Chen TT; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Daya M; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Ding Y; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA., Feng YA; Division of Biostatistics, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Guare LA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gignoux CR; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Hornsby WE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Ingold N; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Ismail SI; Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar., Johnson R; Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lv J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Moreno-Grau S; Galatea Bio, Inc., Hialeah, FL, USA., Nam K; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Palta P; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Pandit A; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Saad C; Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar., Setia-Verma S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Thorsteinsdottir U; deCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland., Uzunovic J; Ontario Institute for Cancer Research, Toronto, ON, Canada., Verma A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Zawistowski M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhong X; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Afifi N; Qatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar., Al-Dabhani KM; Qatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar., Al Thani A; Qatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar., Bradford Y; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Crooks K; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., de Bock GH; Department of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Douville NJ; Department of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.; Institute of Healthcare Policy & Innovation, University of Michigan, Ann Arbor, MI, USA., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Fritsche LG; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Fthenou E; Qatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar., Gonzalez-Arroyo G; Galatea Bio, Inc., Hialeah, FL, USA.; Amphora Health, Morelia, Michoacan, Mexico., Griffiths CJ; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Guo Y; Chinese Academy of Medical Sciences, Beijing, China., Hunt KA; Blizard Institute, Queen Mary University of London, London, UK., Ioannidis A; Galatea Bio, Inc., Hialeah, FL, USA.; Stanford University School of Medicine, Stanford, CA, USA., Jansonius NM; University of Groningen, UMCG, Department of Ophthalmology, Groningen, the Netherlands., Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.; Central Pharmaceutical Research Institute, Japan Tobacco, Inc., Takatsuki 569-1125, Japan., Lee MTM; Galatea Bio, Inc., Hialeah, FL, USA., Lopez-Pineda A; Galatea Bio, Inc., Hialeah, FL, USA.; Amphora Health, Morelia, Michoacan, Mexico., Matsuda Y; Genomelink, Inc., Berkeley, CA, USA., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Moatamed B; Galatea Bio, Inc., Hialeah, FL, USA., Nava-Aguilar MA; Galatea Bio, Inc., Hialeah, FL, USA.; Amphora Health, Morelia, Michoacan, Mexico., Numakura K; Genomelink, Inc., Berkeley, CA, USA., Patil S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Rafaels N; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Richmond A; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Rojas-Muñoz A; Galatea Bio, Inc., Hialeah, FL, USA., Shortt JA; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Straub P; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Tao R; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Vernekar M; Genomelink, Inc., Berkeley, CA, USA., Veturi Y; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Barnes KC; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Boezen M; Department of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Chen CY; Biogen, Cambridge, MA, USA., Cho J; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smith GD; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Bristol Biomedical Research Centre, Bristol, UK., Finucane HK; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Franke L; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands., Gamazon ER; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Ganna A; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Bristol Biomedical Research Centre, Bristol, UK., Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Huang H; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huffman J; Centre for Population Genomics, VA Boston Healthcare System, Boston, MA, USA., Katsanis N; Galatea Bio, Inc., Hialeah, FL, USA., Koskela JT; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Lajonchere C; Institute of Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Law MH; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Lindgren CM; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark., MacGregor S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Matsuda K; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Olsen CM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Shavit JA; University of Michigan, Department of Pediatrics, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Snieder H; Department of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands., Takano T; Genomelink, Inc., Berkeley, CA, USA., Trembath RC; School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Vonk JM; Department of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands., Whiteman DC; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Wicks SJ; University of Colorado - Anschutz Medical Campus, Aurora, CO, USA., Wijmenga C; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands., Wright J; Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK., Zheng J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK., Zhou X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Awadalla P; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bustamante CD; Galatea Bio, Inc., Hialeah, FL, USA.; Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Cox NJ; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Fatumo S; The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.; London School of Hygiene & Tropical Medicine, London, UK.; Medical Research Council/Uganda Virus Research Institute/London School of Hygiene and Tropical Medicine (MRC/UVRI/LSHTM) Uganda Research Unit, Entebbe, Uganda., Geschwind DH; Institute of Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee S; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.; Department of Public Health & Medical Humanities, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Mbarek H; Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Martin HC; Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita 565-0871, Japan., Palotie AV; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Pasaniuc B; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.; Institute of Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sanna S; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.; Institute for Genetics and Biomedical Research (IRGB), National Research Council (CNR), Cagliari, Italy., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Stefansson K; deCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Martin AR; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Neale BM; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jazyk:	angličtina
Zdroj:	Cell genomics [Cell Genom] 2022 Oct 12; Vol. 2 (10), pp. 100192. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2022).
DOI:	10.1016/j.xgen.2022.100192
Abstrakt:	Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits. Competing Interests: M.J.D. is a founder of Maze Therapeutics. B.M.N. is a member of the scientific advisory board at Deep Genomics and a consultant for Camp4 Therapeutics, Takeda Pharmaceutical, and Biogen. The spouse of C.J.W. works at Regeneron Pharmaceuticals. C.-Y.C. is employed by Biogen. C.R.G. owns stock in 23andMe, Inc. T.R.G. has received research funding from various pharmaceutical companies to support the application of Mendelian randomization to drug target prioritization. E.E.K. has received speaker fees from Regeneron, Illumina, and 23andMe and is a member of the advisory board for Galateo Bio. R.E.M. has received speaker fees from Illumina and is a scientific advisor to the Epigenetic Clock Development Foundation. G.D.S. has received research funding from various pharmaceutical companies to support the application of Mendelian randomization to drug target prioritization. K.S. and U.T. are employed by deCODE Genetics/Amgen, Inc. J.Z. has received research funding from various pharmaceutical companies to support the application of Mendelian randomization to drug target prioritization. S.M. is a co-founder of and holds stock in Seonix Bio. (© 2022.)
Databáze:	MEDLINE
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