| Autor: |
van den Brink LM; Department of Farm Animal Health, Utrecht University, 3584 CL Utrecht, The Netherlands., Cohrs I; Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hanover, Germany.; Clinic for Ruminants, Justus-Liebig-University Giessen, Frankfurter Strasse 104, 35392 Giessen, Germany., Golbeck L; Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hanover, Germany.; Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Salisburylaan 133, 9820 Merelbeke, Belgium., Wächter S; Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hanover, Germany., Dobbelaar P; Department of Farm Animal Health, Utrecht University, 3584 CL Utrecht, The Netherlands., Teske E; Department of Clinical Sciences, Utrecht University, 3584 CM Utrecht, The Netherlands., Grünberg W; Department of Farm Animal Health, Utrecht University, 3584 CL Utrecht, The Netherlands.; Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hanover, Germany.; Clinic for Ruminants, Justus-Liebig-University Giessen, Frankfurter Strasse 104, 35392 Giessen, Germany. |
| Abstrakt: |
Postparturient hemoglobinuria is a sporadic disease characterized by intravascular hemolysis and hemoglobinuria in early lactating dairy cows. The condition has empirically been associated with phosphorus (P) deficiency or hypophosphatemia; however, the exact etiology remains obscure. This paper summarizes two controlled studies investigating the effect of P deprivation during the transition period. In Study I, 36 late pregnant dairy cows were randomly assigned to either a diet with low, or adequate, P content from four weeks before calving to four weeks after calving. In Study II, 30 late pregnant dairy cows were again assigned to either a diet with low, or adequate, P for the last four weeks before calving only. Pronounced hypophosphatemia developed during periods of restricted P supply. In early lactation, a subtle decline of the red blood cell count occurred independently of the dietary P supply. In Study I, anemia developed in 11 cows on deficient P supply, which was associated with hemoglobinuria in five cases. Neither erythrocyte total P content nor osmotic resistance of erythrocytes were altered by dietary P deprivation. Restricted dietary P supply, particularly in early lactation, may lead to postparturient hemoglobinuria, but more frequently causes clinically inapparent hemolysis and anemia in cows. |
