Diffusion-Weighted Imaging of the Orbit: A Case Series and Systematic Review.

Autor:	Gupta L; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio., Peterson EL; Department of Ophthalmology, University of Kentucky, Lexington, Kentucky., Williams C; Department of Ophthalmology, University of Kentucky, Lexington, Kentucky., Altman E; Department of Ophthalmology, University of Kentucky, Lexington, Kentucky., Harpole R; Department of Ophthalmology, University of Kentucky, Lexington, Kentucky., Martin DJ; Department of Radiology, Case Western Reserve University, Cleveland, Ohio., Escott EJ; Department of Radiology, Division of Neuroradiology, University of Kentucky Medical Center, Lexington, Kentucky., Timoney PJ; Department of Ophthalmology, University of Kentucky, Lexington, Kentucky., Prendes MA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio.
Jazyk:	angličtina
Zdroj:	Ophthalmic plastic and reconstructive surgery [Ophthalmic Plast Reconstr Surg] 2023 Sep-Oct 01; Vol. 39 (5), pp. 407-418. Date of Electronic Publication: 2023 Feb 09.
DOI:	10.1097/IOP.0000000000002325
Abstrakt:	Purpose: To describe the findings of diffusion-weighted imaging (DWI) for a series of orbital lesions and provide a systematic review of relevant literature. Methods: A retrospective review of 20 patients with orbital lesions who underwent MRI with DWI at two academic institutions between 2015 and 2020 was performed. Lesion diagnosis was histopathologically confirmed except a presumed cavernous hemangioma. Echoplanar diffusion-weighted images had been acquired using 2 or 3 b values (b=0 and 1000 or b=0, 500, and 1000) at 1.5T or 3T. Lesions with significant artifacts were excluded. DWI sequences were analyzed by neuro-radiologists blinded to the diagnosis. Mean ADC values of lesions were calculated from a single region of interest. An independent two-tailed t test was used to compare categories of lesions with p < 0.05 considered significant. A systematic review of the literature was performed. Results: Our study included 21 lesions. ADC values were significantly lower for malignant lesions (0.628 ± 0.125 × 10 -3 mm 2 /s) than inflammatory lesions (1.167 ± 0.381 × 10 -3 mm 2 /s) ( p < 0.001). ADC values were significantly lower for orbital lymphoma (mean 0.621 ± 0.147 × 10 -3 mm 2 /s) than idiopathic orbital inflammation (mean 1.188 ± 0.269 × 10 -3 mm 2 /s) with no overlap ( p < 0.001). Conclusions: Orbital malignancies demonstrated lower ADC values, while inflammatory processes demonstrated higher ADC values, except IgG4-related disease. DWI and ADC values differentiated idiopathic orbital inflammation from orbital lymphoma. This study highlights the role of DWI in evaluating orbital pathology. Competing Interests: The authors have no financial or conflicts of interest to disclose. (Copyright © 2023 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.)
Databáze:	MEDLINE
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