Predictors for Recurrence of Cytomegalovirus Retinitis in HIV-Negative Patients.

Autor:	Tungsattayathitthan U; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Singcanvanit R; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Choopong P; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Jaru-Ampornpan P; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Tesavibul N; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Sopitviriyaporn W; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand., Boonsopon S; Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand.
Jazyk:	angličtina
Zdroj:	Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Jul; Vol. 32 (5), pp. 493-500. Date of Electronic Publication: 2023 Feb 07.
DOI:	10.1080/09273948.2023.2170250
Abstrakt:	Purpose: To investigate the incidence of and predictive factors for recurrent cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)-negative patients. Methods: A retrospective review of HIV-negative patients who were newly diagnosed with CMVR between January 2005 and February 2019. Results: Of 28 patients (44 eyes), 35.9% of eyes had a recurrence of CMVR after discontinuation of anti-CMV therapy. The incidence of CMVR recurrence was 17 per 100 eye-years. The factors significantly associated with CMVR recurrence were eyes with retinitis area of more than 25% ( P = .013), absence of vitreous haze ( P = .003), neutropenia at presentation ( P = .001), and absence of systemic immunosuppression therapy prior to presentation ( P = .002). Conclusion: Eyes with a large area of retinitis, absence of vitreous haze, and neutropenia at presentation are predictive of CMVR recurrence while receiving systemic immunosuppression prior to CMVR presentation has a lower risk of CMVR recurrence.
Databáze:	MEDLINE
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