| Autor: |
Paiva KM; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., Oliveira RF; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., Morais de Freitas LH; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., de Mendonça Florêncio de Melo AM; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., da Rocha GS; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., Freire KF; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil., Souza Cavalcante J; Department of Physiology, Federal University of Rio Grande do Norte; Campus Universitário UFRN - Lagoa Nova, Natal - RN, Brazil., de Gois Morais PLA; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil; pauloleonardo87@hotmail.com., de Paiva Cavalcanti JRL; Department of Biomedical Sciences, University of the State of Rio Grande do Norte, Aeroporto, Mossoró - RN, Brazil. |
| Abstrakt: |
Brain benefits from physical exercise associated with antioxidant supplements such as flaxseed oil. This low cost and simple association may improve hippocampal plasticity, which may work as a preventive and effective therapy in neuroprotection and neuroplasticity processes. This work evaluated the effects of physical exercise with flaxseed oil supplementation (Linum usitatissimum L.) in the hippocampus of Wistar rats. We separated male Wistar rats into four experimental groups: control group (sedentary), a sedentary group with a supplemental diet of flaxseed oil, a group under exercise program with flaxseed oil supplementation, and a group exclusively under exercise program. The swimming exercise consisted of a progressive 28‑day protocol followed by behavioral assessment, brain perfusion, microtomy, immunohistochemistry for glial fibrillary acidic protein (GFAP), cellular morphology, and optical density analysis. We used the ANOVA test with Tukey's post‑test for behavioral analysis. The exercise program with flaxseed oil supplementation was able to alter the GFAP expression in astrocytes in the CA1, CA3 and dentate gyrus regions of the hippocampus and modulate the behavioral aspects of memory and anxiety. |
