The male patient with obesity undergoing metabolic and bariatric surgery: changes in testosterone levels correlate with weight loss after one-anastomosis gastric bypass and Roux-en-Y gastric bypass.

Autor:	Jedamzik J; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Bichler C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Felsenreich DM; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Brugger J; Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Section for Medical Statistics, Medical University of Vienna, Vienna, Austria., Eichelter J; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Nixdorf L; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Krebs M; Division of Endocrinology, Department of Internal Medicine, Medical University of Vienna, Vienna, Austria., Itariu B; Division of Endocrinology, Department of Internal Medicine, Medical University of Vienna, Vienna, Austria., Langer FB; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Prager G; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. Electronic address: gerhard.prager@meduniwien.ac.at.
Jazyk:	angličtina
Zdroj:	Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery [Surg Obes Relat Dis] 2023 Jul; Vol. 19 (7), pp. 699-705. Date of Electronic Publication: 2022 Dec 30.
DOI:	10.1016/j.soard.2022.12.034
Abstrakt:	Background: Male obesity secondary hypogonadism (MOSH) is a common disease among men with obesity and can be associated with metabolic syndrome and a variety of metabolic problems ultimately leading to androgen deficiency. Metabolic and bariatric surgery is a well-established treatment option associated with significant weight loss and reduction in metabolic co-morbidities. Objectives: To evaluate the impact of surgery on plasma levels of sexual hormones and their effect on weight loss comparing 2 surgical methods (one-anastomosis gastric bypass [OAGB] and Roux-en-Y gastric bypass [RYGB]) in male patients with obesity. Setting: University hospital, Austria. Methods: Patients undergoing OAGB and RYGB between 2012 and 2017 were analyzed retrospectively. Follow-up in this study was up to 24 months. Systemic levels of sexual hormones (luteinizing hormone [LH]), follicle stimulating hormone [FSH], total testosterone [TT], sexual hormone binding globin [SHBG], 17 beta-estradiol [17bE], androstenedione [AS]) were retrieved at each visit. A linear mixed model was used to assess the correlation between changes in testosterone levels and percent excess weight loss (%EWL). Results: In 30.8% of all patients, MOSH was present preoperatively. A significant increase of TT was observed postoperatively that led to a complete resolution of hypogonadism within the period observed. Bioavailable testosterone (bTT) and FSH levels significantly increased each month of follow-up after surgery (all P < .01). Levels of 17bE did not change significantly after surgery. The overall change of TT, comparing preoperative and 1-year postoperative TT levels (ΔTT), significantly correlated with %EWL. Changes in TT levels were not affected by the choice of surgical method. Conclusions: Serum plasma testosterone levels rise significantly after metabolic and bariatric surgery in male patients. The change of testosterone levels seems to play a role in continued weight loss after surgery. This is true irrespective of the surgical method used. (Copyright © 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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