Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings.

Autor: Doherty C; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK., Byrne CV; 3M Medical Solutions Division. King Edward Court, King Edward Road, Knutsford, Cheshire, WA16 0BE, UK., Baqader S; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.; Community Nursing and Healthcare Department, Faculty of Nursing, Umm Al-Qura University, Mecca, Saudi Arabia., El-Chami C; School of Biological Sciences, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK., McBain AJ; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. andrew.mcbain@manchester.ac.uk., Thomason HA; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. hthomason@mmm.com.; 3M Medical Solutions Division. King Edward Court, King Edward Road, Knutsford, Cheshire, WA16 0BE, UK. hthomason@mmm.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Feb 03; Vol. 13 (1), pp. 2014. Date of Electronic Publication: 2023 Feb 03.
DOI: 10.1038/s41598-022-26856-x
Abstrakt: Microbial growth within a wound often manifests as biofilms, which can prevent healing and is difficult to eradicate. Novel silver dressings claim to combat wound infection, but anti-biofilm efficacy and effects on healing independent of infection are often unclear. Using in vitro and in vivo S. aureus and P. aeruginosa biofilm models, we report the efficacy of a dressing which produces Ag 1+ ions; an Ag 1+ dressing containing ethylenediaminetetraacetic acid and benzethonium chloride (Ag 1+ /EDTA/BC), and a dressing containing silver oxynitrate (Ag Oxysalts) which produces Ag 1+ , Ag 2+ and Ag 3+ ions, against wound biofilms, and their effects on healing. Ag 1+ dressings had minimal effect on in vitro and murine (C57BL/6j) wound biofilms. In contrast, Ag Oxysalts and Ag 1+ /EDTA/BC dressings significantly reduced viable bacteria within in vitro biofilms and demonstrated a visible reduction in bacteria and EPS components within murine wound biofilms. The dressings had different effects on the healing of biofilm-infected and uninfected wounds, with Ag Oxysalts dressings having a greater beneficial effect on re-epithelialisation, wound size and inflammation than the control treatment and the other silver dressings. The different physicochemical properties of the silver dressings result in varied effects on wound biofilms and healing which should be considered when selecting dressings to treat biofilm-infected wounds.
(© 2023. The Author(s).)
Databáze: MEDLINE
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