Endocrine disorders and fertility and pregnancy: An update.

Autor:	Bendarska-Czerwińska A; Department of Molecular, Biology Gyncentrum Fertility Clinic, Katowice, Poland.; Faculty of Medicine, Academy of Silesia, Zabrze, Poland.; American Medical Clinic, Katowice, Poland., Zmarzły N; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland., Morawiec E; Department of Molecular, Biology Gyncentrum Fertility Clinic, Katowice, Poland.; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland.; Department of Microbiology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland., Panfil A; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland., Bryś K; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland., Czarniecka J; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland., Ostenda A; Faculty of Medicine, Academy of Silesia, Zabrze, Poland., Dziobek K; Faculty of Medicine, Academy of Silesia, Zabrze, Poland., Sagan D; Medical Center Dormed Medical SPA, Busko-Zdroj, Poland., Boroń D; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland.; Department of Gynaecology and Obstetrics, Faculty of Medicine, Academy of Silesia, Zabrze, Poland.; Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland.; Department of Gynecology and Obstetrics, TOMMED Specjalisci od Zdrowia, Katowice, Poland., Michalski P; Faculty of Medicine, Academy of Silesia, Zabrze, Poland., Pallazo-Michalska V; Faculty of Medicine, Academy of Silesia, Zabrze, Poland., Grabarek BO; Department of Molecular, Biology Gyncentrum Fertility Clinic, Katowice, Poland.; Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Academy of Silesia in Katowice, Zabrze, Poland.; Department of Gynaecology and Obstetrics, Faculty of Medicine, Academy of Silesia, Zabrze, Poland.; Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland.; Department of Gynecology and Obstetrics, TOMMED Specjalisci od Zdrowia, Katowice, Poland.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jan 17; Vol. 13, pp. 970439. Date of Electronic Publication: 2023 Jan 17 (Print Publication: 2022).
DOI:	10.3389/fendo.2022.970439
Abstrakt:	It is estimated that more and more couples suffer from fertility and pregnancy maintenance disorders. It is associated with impaired androgen secretion, which is influenced by many factors, ranging from genetic to environmental. It is also important to remember that fertility disorders can also result from abnormal anatomy of the reproductive male and female organ (congenital uterine anomalies - septate, unicornuate, bicornuate uterus; acquired defects of the uterus structure - fibroids, polyps, hypertrophy), disturbed hormonal cycle and obstruction of the fallopian tubes resulting from the presence of adhesions due to inflammation, endometriosis, and surgery, abnormal rhythm of menstrual bleeding, the abnormal concentration of hormones. There are many relationships between the endocrine organs, leading to a chain reaction when one of them fails to function properly. Conditions in which the immune system is involved, including infections and autoimmune diseases, also affect fertility. The form of treatment depends on infertility duration and the patient's age. It includes ovulation stimulation with clomiphene citrate or gonadotropins, metformin use, and weight loss interventions. Since so many different factors affect fertility, it is important to correctly diagnose what is causing the problem and to modify the treatment regimen if necessary. This review describes disturbances in the hormone secretion of individual endocrine organs in the context of fertility and the maintenance of pregnancy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Bendarska-Czerwińska, Zmarzły, Morawiec, Panfil, Bryś, Czarniecka, Ostenda, Dziobek, Sagan, Boroń, Michalski, Pallazo-Michalska and Grabarek.)
Databáze:	MEDLINE
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