Air pollution associated with incidence and progression trajectory of chronic lung diseases: a population-based cohort study.

Autor:	Wang X; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Chen L; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Cai M; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Tian F; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Zou H; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Qian ZM; Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA., Zhang Z; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Li H; Department of Social Medicine and Health Service Management, Shenzhen University, Shenzhen, Guangdong, People's Republic of China., Wang C; College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China., Howard SW; Department of Health Management and Policy, College for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA., Peng Y; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi, People's Republic of China., Zhang L; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi, People's Republic of China., Bingheim E; Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA., Lin H; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China linhualiang@mail.sysu.edu.cn zouyunfeng@gxmu.edu.cn., Zou Y; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi, People's Republic of China linhualiang@mail.sysu.edu.cn zouyunfeng@gxmu.edu.cn.; Department of Toxicology, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Jazyk:	angličtina
Zdroj:	Thorax [Thorax] 2023 Jul; Vol. 78 (7), pp. 698-705. Date of Electronic Publication: 2023 Feb 02.
DOI:	10.1136/thorax-2022-219489
Abstrakt:	Background: No prior study has examined the effects of air pollution on the progression from healthy to chronic lung disease, subsequent chronic lung multimorbidity and further to death. Methods: We used data from the UK Biobank of 265 506 adults free of chronic lung disease at recruitment. Chronic lung multimorbidity was defined as the coexistence of at least two chronic lung diseases, including asthma, chronic obstructive pulmonary disease and lung cancer. The concentrations of air pollutants were estimated using land-use regression models. Multistate models were applied to assess the effect of air pollution on the progression of chronic lung multimorbidity. Results: During a median follow-up of 11.9 years, 13 863 participants developed at least one chronic lung disease, 1055 developed chronic lung multimorbidity and 12 772 died. We observed differential associations of air pollution with different trajectories of chronic lung multimorbidity. Fine particulate matter showed the strongest association with all five transitions, with HRs (95% CI) per 5 µg/m 3 increase of 1.31 (1.22 to 1.42) and 1.27 (1.01 to 1.57) for transitions from healthy to incident chronic lung disease and from incident chronic lung disease to chronic lung multimorbidity, and 1.32 (1.21 to 1.45), 1.24 (1.01 to 1.53) and 1.91 (1.14 to 3.20) for mortality risk from healthy, incident chronic lung disease and chronic lung multimorbidity, respectively. Conclusion: Our study provides the first evidence that ambient air pollution could affect the progression from free of chronic lung disease to incident chronic lung disease, chronic lung multimorbidity and death. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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