Behavior of In Utero Stressed Rats in the Elevated Plus Maze Test during Different Periods of Postnatal Ontogeny.

Autor: Martyusheva AS; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. org.otd.niinf@yandex.ru., Subbotina AY; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Abramova AY; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Pertsov SS; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Jan; Vol. 174 (3), pp. 291-294. Date of Electronic Publication: 2023 Feb 01.
DOI: 10.1007/s10517-023-05693-6
Abstrakt: We studied the effect of prenatal stress (dams were forced to swim in cold water (10°C; 5 min) from day 10 to 16 of gestation) on the behavioral parameters of the offspring in an elevated plus maze on days 21, 30, and 60 of life (suckling, infantile, and juvenile ages, respectively). Females at the suckling age demonstrated suppressed orientation and exploratory activity and increased anxiety, which returned to normal by the infantile and juvenile periods. Prenatally stressed males in juvenile age were characterized by reduced anxiety (assessed by the time spent in the closed and open arms of the plus maze). Thus, the effect of prenatal stress on the behavioral parameters manifested differently depending on the sex and stage of postnatal ontogeny. The modulatory effects of prenatal stress on the analyzed behavioral parameters were more pronounced in females at early stages of postnatal ontogeny (suckling and infantile ages).
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: