Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study.

Autor: Gustavson DE; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Coleman PL; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang Y; Department of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA., Nitin R; Department of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Petty LE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bush CT; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Mosing MA; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany.; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Wesseldijk LW; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany.; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Ullén F; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Cox NJ; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Gordon RL; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2023 Mar; Vol. 1521 (1), pp. 140-154. Date of Electronic Publication: 2023 Jan 30.
DOI: 10.1111/nyas.14964
Abstrakt: Uncovering the genetic underpinnings of musical ability and engagement is a foundational step for exploring their wide-ranging associations with cognition, health, and neurodevelopment. Prior studies have focused on using twin and family designs, demonstrating moderate heritability of musical phenotypes. The current study used genome-wide complex trait analysis and polygenic score (PGS) approaches utilizing genotype data to examine genetic influences on two musicality traits (rhythmic perception and music engagement) in N = 1792 unrelated adults in the Vanderbilt Online Musicality Study. Meta-analyzed heritability estimates (including a replication sample of Swedish individuals) were 31% for rhythmic perception and 12% for self-reported music engagement. A PGS derived from a recent study on beat synchronization ability predicted both rhythmic perception (β = 0.11) and music engagement (β = 0.19) in our sample, suggesting that genetic influences underlying self-reported beat synchronization ability also influence individuals' rhythmic discrimination aptitude and the degree to which they engage in music. Cross-trait analyses revealed a modest contribution of PGSs from several nonmusical traits (from the cognitive, personality, and circadian chronotype domains) to individual differences in musicality (β = -0.06 to 0.07). This work sheds light on the complex relationship between the genetic architecture of musical rhythm processing, beat synchronization, music engagement, and other nonmusical traits.
(© 2023 New York Academy of Sciences.)
Databáze: MEDLINE
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