Human threat learning is associated with gut microbiota composition.

Autor:	Oyarzun JP; Department of Psychology, Harvard University, Cambridge, MA 02138, USA.; Center for Neural Science and Department of Psychology, New York University, New York NY, 10003, USA., Kuntz TM; Department of Biostatistics, Microbiome Analysis Core, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Stussi Y; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Karaman OT; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Vranos S; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Callaghan BL; Department of Psychology, UCLA, Los Angeles, CA 90095, USA., Huttenhower C; Department of Biostatistics, Microbiome Analysis Core, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., LeDoux JE; Center for Neural Science and Department of Psychology, New York University, New York NY, 10003, USA.; Department of Psychiatry and Department of Child and Adolescent Psychiatry, New York University Langone Medical School, New York, NY 1003,USA., Phelps EA; Department of Psychology, Harvard University, Cambridge, MA 02138, USA.; Center for Brain Science, Harvard University, Cambridge, MA, 02138, USA.
Jazyk:	angličtina
Zdroj:	PNAS nexus [PNAS Nexus] 2022 Dec 02; Vol. 1 (5), pp. pgac271. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2022).
DOI:	10.1093/pnasnexus/pgac271
Abstrakt:	The ability to learn about threat and safety is critical for survival. Studies in rodent models have shown that the gut microbiota can modulate such behaviors. In humans, evidence showing an association with threat or extinction learning is lacking. Here, we tested whether individual variability in threat and extinction learning was related to gut microbiota composition in healthy adults. We found that threat, but not extinction learning, varies with individuals' microbiome composition. Our results provide evidence that the gut microbiota is associated with excitatory threat learning across species. (© The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences.)
Databáze:	MEDLINE
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