TAM receptor signaling dictates lesion location and clinical phenotype during experimental autoimmune encephalomyelitis.

Autor: Gardner AM; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; Graduate Program in Immunology, University of Michigan Medical School, 2978 Taubman Health Sciences Library, 1135 Catherine, Ann Arbor, MI 48109, USA. Electronic address: amunie@umich.edu., Atkinson JR; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA. Electronic address: jeffrey.atkinson@osumc.edu., Wilkinson NM; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA. Electronic address: nwilkinson@mednet.ucla.edu., Jerome AD; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA. Electronic address: andrew.jerome@osumc.edu., Bellinger CE; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; Neuroscience Graduate Program, The Ohio State University, 255 Institute for Behavioral Medicine Research Building (IBMR), 460 Medical Center Drive, Columbus, OH 43210, USA. Electronic address: calli.bellinger@osumc.edu., Sas AR; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA. Electronic address: andrew.sas@osumc.edu., Segal BM; Department of Neurology, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA; The Neuroscience Research Institute, The Ohio State University, 395 W. 12th Ave., 7th Floor, Columbus, OH 43210, USA. Electronic address: benjamin.segal@osumc.edu.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2023 Feb 15; Vol. 375, pp. 578016. Date of Electronic Publication: 2023 Jan 20.
DOI: 10.1016/j.jneuroim.2023.578016
Abstrakt: Experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of Th17 cells, typically presents with ascending paralysis and inflammatory demyelination of the spinal cord. Brain white matter is relatively spared. Here we show that treatment of Th17 transfer recipients with a highly selective inhibitor to the TAM family of tyrosine kinase receptors results in ataxia associated with a shift of the inflammatory infiltrate to the hindbrain parenchyma. During homeostasis and preclinical EAE, hindbrain microglia express high levels of the TAM receptor Mer. Our data suggest that constitutive TAM receptor signaling in hindbrain microglia confers region-specific protection against Th17 mediated EAE.
Competing Interests: Declaration of Competing Interest The authors have no conflict of interest to report.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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