Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients.

Autor:	Kempers EK; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., van Kwawegen CB; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., de Meris J; Netherlands Hemophilia Society, Leiden, The Netherlands., Spaander MCW; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Schols SEM; Department of Hematology, Radboud University Medical Center, Nijmegen and Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, The Netherlands., Ypma PF; Department of Hematology, Haga Hospital, The Hague, The Netherlands., Heubel-Moenen FCJI; Department of Hematology, Maastricht University Medical Center, Maastricht, The Netherlands., van Vulpen LFD; Benign Hematology Center, Van Creveldkliniek, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Coppens M; Amsterdam UMC Location University of Amsterdam, Vascular Medicine, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension & Thrombosis, Amsterdam, The Netherlands., van der Bom JG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Fijnvandraat K; Amsterdam UMC Location University of Amsterdam, Department of Pediatric Hematology, Amsterdam, The Netherlands; Sanquin Research, Department of Molecular Hematology, Amsterdam, The Netherlands; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Meijer K; Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands., Eikenboom J; Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Gouw SC; Amsterdam UMC Location University of Amsterdam, Department of Pediatric Hematology, Amsterdam, The Netherlands., Leebeek FWG; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Kruip MJHA; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: m.kruip@erasmusmc.nl.
Jazyk:	angličtina
Zdroj:	Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2023 May; Vol. 21 (5), pp. 1177-1188. Date of Electronic Publication: 2022 Dec 22.
DOI:	10.1016/j.jtha.2022.12.004
Abstrakt:	Background: The population-based colorectal cancer (CRC) screening program in individuals aged 55 to 75 years in the Netherlands uses fecal immunochemical testing (FIT), to detect hemoglobin in feces, followed by colonoscopy in individuals with a positive FIT. Objectives: The objectives of this study are to assess the false-positive rate, detection rate, and positive predictive value of FIT for CRC and advanced adenoma (AA) in patients with Von Willebrand disease (VWD) or hemophilia. Methods: We performed a multicenter, nationwide cross-sectional study embedded in 2 nationwide studies on VWD and hemophilia in the Netherlands. Results: In total, 493 patients with hemophilia (n = 329) or VWD (n = 164) were included, of whom 351 patients participated in the CRC screening program (71.2%). FIT positivity and false-positive rate in patients with hemophilia and VWD were significantly higher than those in the general population (14.8% vs. 4.3%, p < .001 and 10.3% vs. 2.3%, p <.001, respectively). In patients with hemophilia, the detection rate of CRC/AA was significantly higher than that in the general male population (4.5% vs. 1.8%, p = .02), and the positive predictive value of FIT for CRC/AA was comparable (32.3% vs. 39.7%, n.s.). In patients with VWD, the detection rate was similar to that of the general population (0.8% vs. 1.4%, n.s.), whereas the positive predictive value was significantly lower than that in the general population (6.3% vs. 36.8%, p = .02). Conclusion: This study indicates that despite a high false-positive rate of FIT in patients with inherited bleeding disorders, the detection rate of CRC and/or AA in hemophilia patients is high. FIT performs different in patients with hemophilia or VWD compared with the general population. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu