Lower Hounsfield Units and Severe Multifidus Sarcopenia Are Independent Predictors of Increased Risk for Proximal Junctional Kyphosis and Failure Following Thoracolumbar Fusion.

Autor:	Pinter ZW; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Mikula AL; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN., Townsley SE; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Salmons Iv HI; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Lakomkin N; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN., Michalopoulos GD; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN., Nassr A; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Freedman BA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Bydon M; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN., Fogelson J; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN., Sebastian AS; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN., Elder BD; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN.
Jazyk:	angličtina
Zdroj:	Spine [Spine (Phila Pa 1976)] 2023 Feb 15; Vol. 48 (4), pp. 223-231. Date of Electronic Publication: 2022 Nov 02.
DOI:	10.1097/BRS.0000000000004517
Abstrakt:	Study Design: Retrospective cohort study. Objective: The purpose of the present study was to assess the impact of sarcopenia on the development of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) following thoracolumbar spine fusion surgery using opportunistic evaluation of paraspinal fatty degeneration on preoperative magnetic resonance imaging. Summary of Background Data: While paraspinal sarcopenia has been shown to have detrimental consequences following posterior cervicothoracic fusions, the impact of paraspinal sarcopenia on PJK and PJF following thoracolumbar spine fusion surgery remains unknown. Materials and Methods: We performed a retrospective review of patients who underwent posterior spine fusion surgery that extended caudally to the pelvis and terminated cranially between T10 and L2 between 2010 and 2017. The cohort was divided into three groups: (1) patients without PJK or PJF, (2) patients with PJK but no PJF, and (3) patients with PJF. Univariate and multivariate analyses were performed to determine risk factors for the development of proximal junctional complications. Results: We identified 150 patients for inclusion in this study. Mean Hounsfield Units at the upper instrumented vertebra (UIV) was 148.3±34.5 in the cohort of patients without PJK or PJF, which was substantially higher than values recorded in the PJK (117.8±41.9) and PJF (118.8±41.8) subgroups (P<0.001). Severe multifidus sarcopenia was identified at a much higher rate in the subgroups of patients who developed PJK (76.0%) and PJF (78.9%) than in the subgroup of patients who developed neither PJK nor PJF (34.0%; P<0.001). Multivariate analysis demonstrated both low HU at the UIV and moderate-severe multifidus sarcopenia to be risk factors for the development of PJK and PJF. Conclusion: The results of this study suggest severe paraspinal sarcopenia and diminished bone density at the UIV impart an increased risk of developing PJK and PJF, while markers of systemic frailty such as modified Frailty Index and Charlson Comorbidity Index are not associated with an increased risk of these complications. Level of Evidence: III. Competing Interests: The authors report no conflicts of interest (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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