Clinical-epidemiological profile of confirmed cases of osteoarticular tuberculosis.

Autor:	Panico CT; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., de Oliveira PRD; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., de Carvalho VC; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., Dos Anjos AM; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., de Melo VFA; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., Lima ALLM; Instituto de Ortopedia e Traumatologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of bone and joint infection [J Bone Jt Infect] 2023 Jan 05; Vol. 8 (1), pp. 11-17. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2023).
DOI:	10.5194/jbji-8-11-2023
Abstrakt:	Introduction : tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. The incidence of TB has increased since the 1980s. Given the increasing prevalence of TB worldwide, osteoarticular TB (OATB) is a significant health problem. Methods : retrospective study of a case series of hospitalized patients with confirmed OATB by culture or histopathological examination who were seen at a reference orthopedic hospital in São Paulo, Brazil, from 2014 to 2019. Results : thirty patients with confirmed bone and joint TB were seen from 2014 to 2019. The main sites of OATB were the spine (83.3 %) and the appendicular skeleton (26.7 %). Indication of surgical treatment was significantly related to the need for hospitalization ( p = 0.009 ) and the increased length of hospital stay ( p = 0.005 ). Presence of sequelae at the end of treatment was correlated with the presence of motor deficit at the time of OATB diagnosis ( p = 0.035 ) as well as with initial presence of functional limitation ( p = 0.025 ) and with high value of C-reactive protein at the end of treatment ( p = 0.037 ). Conclusions : the delay in the onset of clinical and laboratory signs of cases of osteoarticular infections hinders the early diagnosis and treatment of the disease, resulting in major complications sometimes requiring surgical treatment and consequently leading to a prolonged hospital stay, evidence of high inflammatory activities, and the presence of neurological deficits. Competing Interests: The contact author has declared that none of the authors has any competing interests. (Copyright: © 2023 Caroline Thomaz Panico et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu