Effects of coconut oil long-term supplementation in Wistar rats during metabolic syndrome - regulation of metabolic conditions involving glucose homeostasis, inflammatory signals, and oxidative stress.

Autor: Mautone Gomes H; Center of Oxidative Stress Studies, Department of Biochemistry, Institute of Basic Health Sciences - Federal University of Rio Grande do Sul - UFRGS, Brazil. Electronic address: hm.gomes93@gmail.com., Silveira AK; Center of Oxidative Stress Studies, Department of Biochemistry, Institute of Basic Health Sciences - Federal University of Rio Grande do Sul - UFRGS, Brazil., Gasparotto J; Institute of Biomedical Sciences, Departament of Biochemistry, Federal University of Alfenas - UNIFAL, Minas Gerais, Brazil., Bortolin RC; Departamento de Ingeniería Civil y Ambiental, Universidad de La Costa - Barranquilla, Atlántico, Colombia., Terra SR; Hospital Veterinário UNISUL, Universidade do Sul de Santa Catarina, Avenida José Acácio Moreira, 787, Dehon, Tubarão, Santa Catarina, Brasil., Brum PO; Dr Bohr-Gasse 9, Universität Wien, department of microbiology, immunology and genetics, Max Perutz Labs, 1030, Vienna, Austria., Gelain DP; Center of Oxidative Stress Studies, Department of Biochemistry, Institute of Basic Health Sciences - Federal University of Rio Grande do Sul - UFRGS, Brazil., Fonseca Moreira JC; Center of Oxidative Stress Studies, Department of Biochemistry, Institute of Basic Health Sciences - Federal University of Rio Grande do Sul - UFRGS, Brazil.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2023 Apr; Vol. 114, pp. 109272. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1016/j.jnutbio.2023.109272
Abstrakt: This study was designed to evaluate the long-term effects of Fructose (20%) feeding in rats, simulating metabolic syndrome (MetS), and the effects of coconut oil (C.O.) supplementation when administered in a MetS context. MetS is a cluster of systemic conditions that represent an increased chance of developing cardiovascular diseases and type 2 diabetes in the future. C.O. has been the target of media speculation, and recent studies report inconsistent results. C.O. improved glucose homeostasis and reduced fat accumulation in Fructose-fed rats while decreasing the levels of triglycerides (TGs) in the liver. C.O. supplementation also increased TGs levels and fructosamine in serum during MetS, possibly due to white adipose tissue breakdown and high fructose feeding. Pro-inflammatory cytokines IL-1β and TNF-α were also increased in rats treated with Fructose and C.O. Oxidative stress marker nitrotyrosine is increased in fructose-fed animals, and C.O. treatment did not prevent this damage. No significant changes were observed in lipoperoxidation marker 4-Hydroxynonenal; however, fructose feeding increased total conjugated dienes and caused conjugated dienes to switch their conformation from cis-trans to trans-trans, which was not prevented by C.O. treatment. Potential benefits of C.O. have been reported with inconsistent results, and indeed we observed some benefits of C.O. supplementation in aiding weight loss, fat accumulation, and improving glucose homeostasis. Nonetheless, we also demonstrated that long-term C.O. supplementation could present some problematic effects with higher risk for individuals suffering MetS, including increased TGs and fructosamine levels and conformational changes in dienes.
Competing Interests: Declaration of competing interest The authors confirm no conflicts of interest concerning the work described in this manuscript.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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