| Autor: |
Ibrahem HY; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Aly DH; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Warda AEA; Clinical Pharmacy Department, Faculty of Pharmacy, October 6 University, Giza P.O. Box 12585, Egypt., Farahat RA; Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh P.O. Box 33511, Egypt., Youssef RM; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Abdelhamid MH; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Goud HA; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Mohamed RR; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Eldien MAYN; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Alotaibi FO; Forensic Medical Services Center in Riyadh, Ministry of Health, Riyadh 12271, Saudi Arabia., Alzarea AI; Clinical Pharmacy Department, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia., Alanazi AS; Clinical Pharmacy Department, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.; Health Sciences Research Unit, Jouf University, Sakaka 72388, Saudi Arabia., Eisa NM; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt., Refaee AS; Clinical Research Department at Giza Health Affairs Directorate, Ministry of Health and Population, Giza P.O. Box 12511, Egypt. |
| Abstrakt: |
Background and Objectives : Mortality and illness due to COVID-19 have been linked to a condition known as cytokine release syndrome (CRS) that is characterized by excessive production of inflammatory cytokines, particularly interleukin-6 (IL-6). Tocilizumab (TCZ), a recent IL-6 antagonist, has been redeployed as adjunctive treatment for CRS remission in COVID-19 patients. This study aimed to determine the efficacy of Tocilizumab on patients' survival and the length of stay in hospitalized COVID-19 patients admitted to the intensive care unit. Methods : Between January 2021 and June 2021, a multicenter retrospective cohort study was carried out in six tertiary care hospitals in Egypt's governorate of Giza. Based on the use of TCZ during ICU stay, eligible patients were divided into two groups (control vs. TCZ). In-hospital mortality was the main outcome. Results : A total of 740 patient data records were included in the analysis, where 630 patients followed the routine COVID-19 protocol, while 110 patients received TCZ, need to different respiratory support after hospitalization, and inflammatory mediators such as C-reactive protein (CRP), ferritin, and Lactate dehydrogenase (LDH) showed a statistically significant difference between the TCZ group and the control group. Regarding the primary outcome (discharged alive or death) and neither the secondary outcome (length of hospital stay), there is no statistically significant difference between patients treated with TCZ and the control group. Conclusions : Our cohort of patients with moderate to severe COVID-19 did not assert a reduction in the risk of mortality or the length of stay (LOS) after TCZ administration. |
