Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival.

Autor: van den Hoogen P; Laboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Circulatory Health Laboratory, Regenerative Medicine Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Huibers MMH; Department of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.; Department of Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van den Dolder FW; Department of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., de Weger R; Department of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Siera-de Koning E; Department of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Oerlemans MIF; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., de Jonge N; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Laake LW; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Doevendans PA; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Netherlands Heart Institute (NLHI), 3511 EP Utrecht, The Netherlands.; Centraal Militair Hospitaal (CMH), 3584 EZ Utrecht, The Netherlands., Sluijter JPG; Laboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Circulatory Health Laboratory, Regenerative Medicine Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Vink A; Department of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., de Jager SCA; Laboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Circulatory Health Laboratory, Regenerative Medicine Center, Utrecht University, 3584 CX Utrecht, The Netherlands.; Laboratory of Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Biology [Biology (Basel)] 2022 Dec 30; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 30.
DOI: 10.3390/biology12010061
Abstrakt: Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been found in end-stage heart failure (HF) patients prior to HTx. In this study, we aimed to determine whether increased circulating immunoglobulin levels prior to transplantation are associated with poor post-HTx survival. Pre-and post-HTx plasma samples of 36 cardiac transplant recipient patients were used to determine circulating immunoglobulin levels. In addition, epicardial tissue was collected to determine immunoglobulin deposition in cardiac tissue and assess signs and severity of graft rejection. High levels of IgG1 and IgG2 prior to HTx were associated with a shorter survival post-HTx. Immunoglobulin deposition in cardiac tissue was significantly elevated in patients with a survival of less than 3 years. Patients with high plasma IgG levels pre-HTx also had significantly higher plasma levels after HTx. Furthermore, high pre-HTX levels of IgG1 and IgG2 levels were also significantly increased in patients with inflammatory infiltrate in CAV lesions. Altogether the results of this proof-of-concept study suggest that an activated immune response prior to transplantation negatively affects graft survival.
Databáze: MEDLINE
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