Mitigation and use of biofilms in space for the benefit of human space exploration.

Autor:	Vélez Justiniano YA; ECLSS Development Branch, NASA Marshall Space Flight Center, Huntsville, AL, USA., Goeres DM; The Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.; Chemical and Biological Engineering, Montana State University, Bozeman, MT, USA., Sandvik EL; The Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA., Kjellerup BV; Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, USA., Sysoeva TA; Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, AL, USA., Harris JS; Biomedical and Environmental Science Division, NASA Johnson Space Center, Houston, TX, USA., Warnat S; The Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.; Mechanical Engineering, Montana State University, Bozeman, MT, USA., McGlennen M; The Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.; Mechanical Engineering, Montana State University, Bozeman, MT, USA., Foreman CM; The Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.; Chemical and Biological Engineering, Montana State University, Bozeman, MT, USA., Yang J; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA., Li W; Laboratory Support Services and Operations (LASSO), NASA Kennedy Space Center, Cape Canaveral, FL, USA., Cassilly CD; Jacobs Space Exploration Group (ESSCA), Huntsville, AL, USA., Lott K; Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, AL, USA., HerrNeckar LE; ECLSS Development Branch, NASA Marshall Space Flight Center, Huntsville, AL, USA.
Jazyk:	angličtina
Zdroj:	Biofilm [Biofilm] 2023 Jan 06; Vol. 5, pp. 100102. Date of Electronic Publication: 2023 Jan 06 (Print Publication: 2023).
DOI:	10.1016/j.bioflm.2022.100102
Abstrakt:	Biofilms are self-organized communities of microorganisms that are encased in an extracellular polymeric matrix and often found attached to surfaces. Biofilms are widely present on Earth, often found in diverse and sometimes extreme environments. These microbial communities have been described as recalcitrant or protective when facing adversity and environmental exposures. On the International Space Station, biofilms were found in human-inhabited environments on a multitude of hardware surfaces. Moreover, studies have identified phenotypic and genetic changes in the microorganisms under microgravity conditions including changes in microbe surface colonization and pathogenicity traits. Lack of consistent research in microgravity-grown biofilms can lead to deficient understanding of altered microbial behavior in space. This could subsequently create problems in engineered systems or negatively impact human health on crewed spaceflights. It is especially relevant to long-term and remote space missions that will lack resupply and service. Conversely, biofilms are also known to benefit plant growth and are essential for human health (i.e., gut microbiome). Eventually, biofilms may be used to supply metabolic pathways that produce organic and inorganic components useful to sustaining life on celestial bodies beyond Earth. This article will explore what is currently known about biofilms in space and will identify gaps in the aerospace industry's knowledge that should be filled in order to mitigate or to leverage biofilms to the advantage of spaceflight. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Darla M. Goeres reports financial support was provided by NASA Marshall Space Flight Center. Elizabeth L. Sandvik reports financial support was provided by NASA Marshall Space Flight Center. Stephan Warnat reports was provided by NASA Marshall Space Flight Center. Christine M. Foreman reports was provided by NASA Marshall Space Flight Center. Matthew McGlennen reports financial support was provided by NASA Marshall Space Flight Center. Stephan Warnat reports equipment, drugs, or supplieswere provided by the National Science Foundation. First author Yo-Ann Vélez Jutiniano is a guest managing editor in the Biofilms in Space Special issue. Co-authors Darla Goeres and Birthe Veno Kjellerup are senior editors in the Biofilm journal. (© 2022 Published by Elsevier B.V.)
Databáze:	MEDLINE
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