Using Patient Perspectives to Inform Better Clinical Trial Design and Conduct: Current Trends and Future Directions.

Autor: Faulkner SD; Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Rd, Oxford, OX2 6GG, UK. stuart.faulkner@phc.ox.ac.uk., Somers F; UCB Biopharma SRL, Allee de la Recherche 60, 1070, Brussels, Belgium., Boudes M; European Patients' Forum, Chaussée d'Etterbeek 180, Brussels, Belgium., Nafria B; Patient Engagement in Research Department, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.; Innovation Department Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Robinson P; Merck Sharp & Dohme (UK) Ltd., Moorgate, London, UK.
Jazyk: angličtina
Zdroj: Pharmaceutical medicine [Pharmaceut Med] 2023 Mar; Vol. 37 (2), pp. 129-138. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1007/s40290-022-00458-4
Abstrakt: The approach to patient engagement (PE) in drug development has changed rapidly due to many factors, including the complexity of innovative drugs and the need to demonstrate outcomes of relevance to patients, the desire to show 'value add' of PE, and the pandemic-related changes to how clinical trials are run, e.g., decentralised studies. In parallel, there have been changes in technology-assisted ways of running clinical trials, capturing patient health outcomes and preferences, an increasing societal demand for diversity and inclusion, and efforts to improve clinical trial efficiency, transparency, and accountability. Organisations are beginning to monitor PE activities and outcomes more effectively to learn and inform future PE strategies. As a result, these factors are facilitating the incorporation of patients' lived experience, preferences and needs into the design and running of clinical trials more than ever before. In this paper, the authors reflect upon these last few years, the emerging trends and their drivers, and where we may expect PE in clinical research to progress in the near future.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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