Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.

Autor:	Reinhold K; Neurosciences Graduate Program, University of California San Diego, La Jolla, 92093, California kimberly_reinhold@hms.harvard.edu.; Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, 92093, California.; Department of Physiology, University of California San Francisco, San Francisco, 94143, California., Resulaj A; Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, 92093, California.; Department of Physiology, University of California San Francisco, San Francisco, 94143, California.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, 94143, California., Scanziani M; Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, 92093, California.; Department of Physiology, University of California San Francisco, San Francisco, 94143, California.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, 94143, California.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 Mar 01; Vol. 43 (9), pp. 1540-1554. Date of Electronic Publication: 2023 Jan 18.
DOI:	10.1523/JNEUROSCI.2124-21.2022
Abstrakt:	The behavioral state of a mammal impacts how the brain responds to visual stimuli as early as in the dorsolateral geniculate nucleus of the thalamus (dLGN), the primary relay of visual information to the cortex. A clear example of this is the markedly stronger response of dLGN neurons to higher temporal frequencies of the visual stimulus in alert as compared with quiescent animals. The dLGN receives strong feedback from the visual cortex, yet whether this feedback contributes to these state-dependent responses to visual stimuli is poorly understood. Here, we show that in male and female mice, silencing cortico-thalamic feedback profoundly reduces state-dependent differences in the response of dLGN neurons to visual stimuli. This holds true for dLGN responses to both temporal and spatial features of the visual stimulus. These results reveal that the state-dependent shift of the response to visual stimuli in an early stage of visual processing depends on cortico-thalamic feedback. SIGNIFICANCE STATEMENT Brain state affects even the earliest stages of sensory processing. A clear example of this phenomenon is the change in thalamic responses to visual stimuli depending on whether the animal's brain is in an alert or quiescent state. Despite the radical impact that brain state has on sensory processing, the underlying circuits are still poorly understood. Here, we show that both the temporal and spatial response properties of thalamic neurons to visual stimuli depend on the state of the animal and, crucially, that this state-dependent shift relies on the feedback projection from visual cortex to thalamus. (Copyright © 2023 Reinhold, Resulaj et al.)
Databáze:	MEDLINE
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