Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction.

Autor: Lo JO; Department of Obstetrics and Gynecology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L458, Portland, OR, 97239, USA. loj@ohsu.edu.; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA. loj@ohsu.edu., Schabel MC; Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA., Gaffney J; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Lewandowski KS; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Kroenke CD; Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA.; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Roberts CT Jr; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Scottoline BP; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.; Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA., Frias AE; Department of Obstetrics and Gynecology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L458, Portland, OR, 97239, USA., Sullivan EL; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.; Department of Psychiatry, Oregon Health and Science University, Portland, OR, USA., Roberts VHJ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 16; Vol. 13 (1), pp. 841. Date of Electronic Publication: 2023 Jan 16.
DOI: 10.1038/s41598-023-28051-y
Abstrakt: Maternal malnutrition increases fetal and neonatal morbidity, partly by affecting placental function and morphology, but its impact on placental hemodynamics are unknown. Our objective was to define the impact of maternal malnutrition on placental oxygen reserve and perfusion in vivo in a rhesus macaque model of protein restriction (PR) using advanced imaging. Animals were fed control (CON, 26% protein), 33% PR diet (17% protein), or a 50% PR diet (13% protein, n = 8/group) preconception and throughout pregnancy. Animals underwent Doppler ultrasound and fetal biometry followed by MRI at gestational days 85 (G85) and 135 (G135; term is G168). Pregnancy loss rates were 0/8 in CON, 1/8 in 33% PR, and 3/8 in 50% PR animals. Fetuses of animals fed a 50% PR diet had a smaller abdominal circumference (G135, p < 0.01). On MRI, placental blood flow was decreased at G135 (p < 0.05) and placental oxygen reserve was reduced (G85, p = 0.05; G135, p = 0.01) in animals fed a 50% PR diet vs. CON. These data demonstrate that a 50% PR diet reduces maternal placental perfusion, decreases fetal oxygen availability, and increases fetal mortality. These alterations in placental hemodynamics may partly explain human growth restriction and stillbirth seen with severe PR diets in the developing world.
(© 2023. The Author(s).)
Databáze: MEDLINE
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